Results 311 to 320 of about 2,975,301 (351)
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Mechanisms of Bacterial Resistance
Pediatric Clinics of North America, 1995Antibiotic resistance is a growing problem in clinical pediatrics. Many of the agents traditionally used to treat pediatric pathogens are becoming less effective because of increasing bacterial resistance. In addition, many more children are immunocompromised because of primary or acquired immunodeficiencies and because of advances in cancer ...
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Mechanisms of Polymyxin Resistance
2019Polymyxin antibiotics are increasingly being used as last-line therapeutic options against a number of multidrug resistant bacteria. These antibiotics show strong bactericidal activity against a range of Gram-negative bacteria, but with the increased use of these antibiotics resistant strains are emerging at an alarming rate.
Jennifer H, Moffatt +2 more
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Molecular Mechanisms of Patupilone Resistance
Cancer Research, 2008Abstract Patupilone is an epothilone in advanced clinical development that has shown promising efficacy in heavily pretreated patients. This study aimed at characterizing the mechanisms of patupilone activity in resistant patients. To this end, we generated patupilone-resistant cells using two cellular models, the first characterized ...
Mozzetti, Simona +9 more
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Epileptic Disorders, 2005
ABSTRACT Despite the use of new antiepileptic drugs, approximately one third of patients with epilepsy have seizures that cannot be controlled satisfactorily by medical treatment. Drug resistance may exist at the time of the first seizure or may develop later as result of the disease process.
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ABSTRACT Despite the use of new antiepileptic drugs, approximately one third of patients with epilepsy have seizures that cannot be controlled satisfactorily by medical treatment. Drug resistance may exist at the time of the first seizure or may develop later as result of the disease process.
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Biocides – resistance, cross-resistance mechanisms and assessment
Expert Opinion on Investigational Drugs, 2012Antibiotic resistance in bacterial pathogens has increased worldwide leading to treatment failures. Concerns have been raised about the use of biocides as a contributing factor to the risk of antimicrobial resistance (AMR) development. In vitro studies demonstrating increase in resistance have often been cited as evidence for increased risks.
Divya Prakash, Gnanadhas +2 more
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Resistance mechanisms in Enterobacteriaceae
Pathology, 2015Enterobacteriaceae are responsible for a large proportion of serious, life-threatening infections and resistance to multiple antibiotics in these organisms is an increasing global public health problem. Mutations in chromosomal genes contribute to antibiotic resistance, but Enterobacteriaceae are adapted to sharing genetic material and much important ...
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Mechanisms of fluoroquinolone resistance
Drug Resistance Updates, 1999Mechanisms of bacterial resistance to fluoroquinolones fall into two principal categories, alterations in drug target enzymes and alterations that limit permeation of drug to the target, both resulting from chromosomal mutations. No specific resistance mechanisms of quinolone degradation or modification have been found.
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Mechanisms of radiation resistance.
Rays, 1993[No abstract available]
C. Biagini +2 more
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1988
The efficacy of gold treatment in rheumatoid arthritis is hampered by toxicity, most prevalent in early phases, and unresponsiveness which can only be assessed after more than 6 months on therapy. There is some evidence that more severe disease increases the likelihood of drug resistance.
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The efficacy of gold treatment in rheumatoid arthritis is hampered by toxicity, most prevalent in early phases, and unresponsiveness which can only be assessed after more than 6 months on therapy. There is some evidence that more severe disease increases the likelihood of drug resistance.
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Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward
Ca-A Cancer Journal for Clinicians, 2021Amila K Nanayakkara, Kevin Outterson
exaly