Results 101 to 110 of about 1,545,817 (309)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Sites of Resistance: All-Ages Music Venues in their Local and Theoretical Contexts [PDF]

, 2008
This paper shows how all-ages venues resist and contradict basic assumptions behind sociological, cultural policy and "creative cities" approaches to grassroots culture.
Tim Jones, Tim Wood
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Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Slovak National Uprising and the USSR (On the 80th Anniversary)

Славянский мир в третьем тысячелетии
The article is dedicated to the largest event in Slovak history during the Second World War – the Slovak National Uprising (SNU) and is based on the materials from the Russian Foreign Policy Archive, published documents, memoires and scientific research.
Elena P. Serapionova
doaj   +1 more source

Critical Facets of European Corn Borer Adult Movement Ecology Relevant to Mitigating Field Resistance to Bt-Corn

Insects
The European corn borer (Ostrinia nubilalis, Hübner) has been managed successfully in North America since 1996 with transgenic Bt-corn. However, field-evolved resistance to all four available insecticidal Bt proteins has been detected in four provinces ...
Thomas W. Sappington
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

METHOD OF THE DRIVE POWER DETERMINATION OF THE MECHANISMS OF THE BRIDGE CRANE MOVEMENT CONSIDERING THE ROLLING FRICTION

Nauka ta progres transportu, 2015
Purpose. The value of drive resistance to its movement is the main parameter at calculating the drive power of bridge crane. The value of the wheel rolling friction on the rails is one of the important parts of the resistance to movement. It is necessary
V. M. Bohomaz, L. M. Bondarenko, K. Ts. Hlavatskyi, K. O. Sokol   +3 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Theoretical basics and experimental methods of consideration of the concrete mixtures' movement resistance in the concrete-delivery pipelines

MATEC Web of Conferences, 2018
The directions associated with development and improvement in the field of works' production using the concrete and reinforced concrete are related mainly with the improvement of the quality and durability of concrete and products based on it, the ...
Novikov Sergey, Zhadanovsky Boris, Sinenko Sergey   +2 more
doaj   +1 more source

The 1941 miners' strike in northern France: from a dispute over soap to armed resistance [PDF]

, 2006
In Northern France in 1941, while under German military occupation, 100,000 miners went on strike from the 27th May to the 9th June. This strike not only cost the German war machine half a million tonnes of coal, but also had long-term consequences for ...
Cushion, Stephen
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