Results 71 to 80 of about 3,772,305 (302)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan. [PDF]

, 2003
Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected.
Keus, K, Nzila, A, Ochong, E, van den Broek, I   +3 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Organisational readiness for introducing a performance management system

SA Journal of Human Resource Management, 2012
Orientation: The successful introduction of performance management systems to the public service requires careful measurement of readiness for change. Research purpose: This study investigated the extent to which employees were ready for change as an ...
Michael Ochurub, Mark Bussin, Xenia Goosen   +2 more
doaj   +1 more source

The effect of environmental heterogeneity on RPW8-mediated resistance to powdery mildews in Arabidopsis thaliana [PDF]

, 2012
Background and Aims: The biotic and abiotic environment of interacting hosts and parasites may vary considerably over small spatial and temporal scales. It is essential to understand how different environments affect host disease resistance because this ...
Agrios, Boyes, Brown, Burdon, Burdon, Bustin, Carroll, Century, Chongo, Collins, Dawkins, de Jong, Dubuffet, Eitas, Elmore, Fu, Gandon, Gijzen, Gillespie, Jarosz, Jeffery, Jensen, Jones, Jorgensen, Koch, Laine, Laine, Lazzaro, Levene, Lynch, Millett, Mohr, Noutoshi, Oliva, Orgil, Pedley, Pfaffl, Plotnikova, Price, Ramage, Ramakers, Salvaudon, Sander, Sasaki, Shi, Shirasu, Simms, Tan, Tellier, Thompson, Thrall, Tove H. Jorgensen, Vale, Vandesompele, Wang, Wang, Wang, Wang, Wang, Webb, Weinig, Wolinska, Xiao, Xiao, Xiao, Xiao, Yan, Yang, Yang, Yoshimura, Zhu   +70 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Study of the factors that resistance on change in public libraries of West Azerbaijan

تحقیقات اطلاع‌رسانی و کتابخانه‌های عمومی, 2015
Purpose: This study aims to investigate factors that affect resistance to change in the public libraries of West Azerbaijan. Methodology: In this research the analytical survey method was applied.
Mohammad Reza Farhadpoor, Fariba Nazari
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Decreasing the Resistance of the Human Resources to Organizational Changes [PDF]

One of the most difficult problems faced by the management of all organizations within innovation and change processes is the resistance to change. This study, dealing with this issue, has the following main objectives: to identify the main sources of ...
Ciprian NICOLESCU, Ovidiu NICOLESCU
core