Results 81 to 90 of about 20,474 (213)
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
School culture and resistance to change
Tendencias Pedagógicas, 2015 This work analyzes the characteristics of the resistance to the processes of change through the following conditions: the school is the change unit, it's necessary people concerned with the change, those agents need autonomy and power, it's necessary an ...
Joaquín Paredes Labra
doaj
Journal of Medical Education Development, 2020 Background & Objective: Considering the current unstable environment, organizations are faced with numerous changes and should adapt to various environmental factors.
Kosar Momeni Badeleh, Taraneh Enayati
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Bureaucratic Spleen: Europeanization and Resistance to Change in Romanian Public Administration
Sociologie Românească, 2013 In this paper, we analyse the way in which positive communication of European knowledge produces a series of perverse effects at the level of Romanian public administration, effects that take the form of an avoidance strategy.
Amanda Bosovcki
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
انعكاسات الإصلاح التربوي على الأداء الوظيفي للأستاذ
مجلة الآداب و العلوم الإجتماعية, 2014 The education reform is one of the most important driving forces for development. Human societies revitalize their educational systems through reform in order to build an individual who is able to overcome danger, and even participate in change and ...
سعيدة بن عمارة
doaj