Results 101 to 110 of about 3,772,305 (302)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Investigation of the Surface Adhesion Phenomena and Mechanism of Gold-Plated Contacts at Superlow Making/Breaking Speed [PDF]
, 2015 Surface adhesion phenomena of gold-plated copper contact materials are studied in conditions of nonarc load (5/15/25 V and 0.2/0.5/1 A) and superlow speed (25 and 50 nm/s) realized by a piezoactuator during the making and breaking processes.
Chang, Cheng +4 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Mapping the landscape of positive and negative organizations in innovation implementation
Frontiers in CommunicationIntroductionThe successful implementation of innovation is a crucial factor in the survival of organizations in a competitive environment. This study aims to analyze how communication practices in positive and negative organizations influence the ...
Diana Machado +7 more
doaj +1 more source
Oxidation resistant, thoria-dispersed nickel-chromium-aluminum alloy [PDF]
, 1973 Modified thoria-dispersed nickel-chromium alloy has been developed that exhibits greatly improved resistance to high-temperature oxidation. Additions of aluminum have been made to change nature of protective oxide scale entirely and to essentially ...
Baranow, S., Klingler, L. J.
core +1 more source
, 2003 We study the transport properties of a superconducting Nb film with a square lattice of artificial pinning centers (APCs) as a function of dc current, at a temperature close to the superconducting transition temperature of the film.
D. A. Dikin +5 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Longitudinal associations of insulin resistance with change in bone mineral density in midlife women. [PDF]
JCI Insight, 2022 Shieh A +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Switching Behavior in the Polish Energy Market—The Importance of Resistance to Change
Energies(1) Background: Consumer switching behavior was one of the expected outcomes of the ongoing competitive reform in the European electricity industry. The aim of this study is to analyze the factors that affect the intention of consumers to switch from ...
Ilona Lipowska +3 more
doaj +1 more source