Results 31 to 40 of about 87,899,976 (281)

Myt1 overexpression mediates resistance to cell cycle and DNA damage checkpoint kinase inhibitors

Frontiers in Cell and Developmental Biology, 2023
Cell cycle checkpoint kinases serve as important therapeutic targets for various cancers. When they are inhibited by small molecules, checkpoint abrogation can induce cell death or further sensitize cancer cells to other genotoxic therapies. Particularly
Sargun Sokhi, Sargun Sokhi, Sargun Sokhi, Cody W. Lewis, Cody W. Lewis, Cody W. Lewis, Amirali B. Bukhari, Amirali B. Bukhari, Amirali B. Bukhari, Joanne Hadfield, Joanne Hadfield, Joanne Hadfield, Edric J. Xiao, Edric J. Xiao, Edric J. Xiao, Jeremy Fung, Jeremy Fung, Yea Jin Yoon, Yea Jin Yoon, Wen-Hsin Hsu, Wen-Hsin Hsu, Wen-Hsin Hsu, Armin M. Gamper, Armin M. Gamper, Armin M. Gamper, Gordon K. Chan, Gordon K. Chan, Gordon K. Chan   +27 more
doaj   +1 more source

Repeated mechanical damage enhanced Aquilaria sinensis resistance to Heortia vitessoides through jasmonic acid

Frontiers in Plant Science, 2023
IntroductionThe leaf-chewing pest Heortia vitessoides severely threatens the growth and development of Aquilaria sinensis. In our previous study, we found that mechanical damage (MD) to stem enhanced A. sinensis sapling resistance to H.
Yingying Chen, Yingying Chen, Shenghua Liang, Shuyao Wang, Baocai Li, Kun Wang, Yongjin Zhu, Risheng Yang, Xin Hao, Zhuoying Yang, Yingbai Shen, Yingbai Shen, Rihong Jiang, Kaixiang Li   +13 more
doaj   +1 more source

Resistance to Moisture Damage of Recycled Asphalt Concrete Pavement

Journal of Engineering, 2015
Recycled asphalt concrete mixture are prepared, artificially aged and processed in the laboratory to maintain the homogeneity of recycled asphalt concrete mixture gradation, and bitumen content.
saad Isaa Sarsam, Israa Lutfi AL-Zubaidi
doaj   +2 more sources

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Lack of correlation between constitutive and induced resistance to a herbivore in crucifer plants: real or flawed by experimental methods? [PDF]

, 2009
The correlation between constitutive and induced resistance to herbivores in plants has long been of interest to evolutionary biologists, and various approaches to determining levels of resistance have been used in this field of research.
Dicke, M., Liu, S.S., Zhang, P.J., Wu, Z.Y., Shu, J.P.   +4 more
core   +1 more source

Resistance of tree species to snow damage in Nav Asalem forests, Guilan province [PDF]

تحقیقات جنگل و صنوبر ایران, 2014
Management of mountainous forests implies detailed information on the extent and intensity of snow damages. Furthermore, such information is required for improved conservation of natural stands.
Amir Eslam Bonyad, Farzam Tavankar
doaj   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

ZEB1: A Critical Regulator of Cell Plasticity, DNA Damage Response, and Therapy Resistance

Frontiers in Molecular Biosciences, 2020
The predominant way in which conventional chemotherapy kills rapidly proliferating cancer cells is the induction of DNA damage. However, chemoresistance remains the main obstacle to therapy effectivity.
Stanislav Drápela, Stanislav Drápela, Stanislav Drápela, Jan Bouchal, Mohit Kumar Jolly, Zoran Culig, Zoran Culig, Karel Souček, Karel Souček, Karel Souček   +9 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Resistance of Rubberized Asphalt Mixture to Aging and Moisture Damage

International Islamic University Malaysia Engineering Journal
Asphalt pavements in Malaysia suffer severe deterioration, such as raveling and stripping, because the bonding and adhesion between asphalt and aggregate is poor.
Ayman Hassan Al-Qudah, Suhana Koting, Mohd Rasdan Ibrahim, Muna Alibrahim, Nishanthini Jegatheesan   +4 more
doaj   +1 more source