Results 61 to 70 of about 32,295 (302)
A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation
Clinical Pharmacology &Therapeutics, EarlyView.The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix +4 more
wiley +1 more source
A Case Report: Treatment Resistant Schizophrenia [PDF]
Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2004 Clinicians define resistance to treatment of schizophrenia, as a failure including functional and psyhcosocial dimensions despite adequate dosage, duration and treatment consistency.
Gamze Sönmez +5 more
doaj
Epilepsia, EarlyView.Abstract Objective Epilepsy is a highly heterogeneous neurological disorder with significant prognostic variability. Accurate long‐term outcome prediction remains a clinical challenge. We investigated pharmacotherapeutic prognosis and key predictors, particularly baseline seizure timing, to guide individualized treatment.
Lei Sun +3 more
wiley +1 more source
Neuropsychiatric Disease and Treatment, 2022 Juan D Duque-Yemail,1 Juan Carlos Avila2 1Psychiatry Resident, Department of Mental Health, Vall d’Hebron University Hospital, Barcelona, Spain; 2Psychiatrist, Mental Health Center, Badalona, SpainCorrespondence: Juan D Duque-Yemail, Vall d’Hebron ...
Duque-Yemail JD, Avila JC
doaj
Group CBT for people with schizophrenia [PDF]
, 1998 Individual cognitive behavioural interventions for psychosis are rapidly developing and are being shown to be effective. This paper examines the application of these interventions on a group basis. The nature of the group, treatment outcome and potential
Sellwood, William +2 more
core
Reduced dorso-lateral prefrontal cortex in treatment resistant schizophrenia
, 2013 Background: Treatment resistance affects up to one third of patients with schizophrenia (SCZ). A better understanding of its biological underlying processes could improve treatment.
Ota, Vanessa K. [UNIFESP] +21 more
core +1 more source
Brain–Computer Interfaces: The Dawn of a New Era in Disease Treatment
Exploration, EarlyView.This study investigates the potential of brain–computer interface (BCI) technology in treating neuropsychiatric disorders, such as movement and communication barriers. Our review examines the history, signal paradigms, and diverse applications of BCI while also discussing ongoing research into novel materials and emerging technologies that offer ...
Yuqi Feng +11 more
wiley +1 more source
Neurobiology of Disease, 2013 Schizophrenia is a severe and common psychiatric disease with a lifetime prevalence of 0.5% to 1% globally. Because of limitations of the experimental approach in humans, valid animal models are essential in the effort to identify novel therapeutics for ...
Akihiro Mouri +3 more
doaj +1 more source
Roles of histone lysine methylation in neurodevelopment and related disorders
Ibrain, EarlyView.This graphical abstract centers on the theme of dynamic balance and systematically outlines the role of histone lysine methylation in neurodevelopment and related disorders. The figure first presents two key classes of regulators that control this balance—“writers” and “erasers”—and then indicates how interactions among different epigenetic ...
Yun Chen +3 more
wiley +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Theta burst stimulation (TBS) is often used in clinical practice and research protocols for adults with neuropsychiatric disorders. There are substantial knowledge gaps related to the application of TBS in children and adolescents.
Rana Elmaghraby +5 more
wiley +1 more source