Results 121 to 130 of about 5,069,413 (334)

Topics in microphysics of relativistic plasmas

, 2013
Astrophysical plasmas can have parameters vastly different from the more studied laboratory and space plasmas. In particular, the magnetic fields can be the dominant component of the plasma, with energy-density exceeding the particle rest-mass energy ...
Lazarian, Alexandre, Lyutikov, Maxim
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Memristor Crossbar-based Hardware Implementation of IDS Method

, 2010
Ink Drop Spread (IDS) is the engine of Active Learning Method (ALM), which is the methodology of soft computing. IDS, as a pattern-based processing unit, extracts useful information from a system subjected to modeling. In spite of its excellent potential
Bagheri-Shouraki, Saeed, Merrikh-Bayat, Farnood, Rohani, Ali   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Renal Doppler Resistive Index as a Marker of Oxygen Supply and Demand Mismatch in Postoperative Cardiac Surgery Patients

BioMed Research International, 2015
Background and Objective. Renal Doppler resistive index (RDRI) is a noninvasive index considered to reflect renal vascular perfusion. The aim of this study was to identify the independent hemodynamic determinants of RDRI in mechanically ventilated ...
F. Corradi, C. Brusasco, F. Paparo, T. Manca, G. Santori, F. Benassi, A. Molardi, A. Gallingani, A. Ramelli, T. Gherli, A. Vezzani   +10 more
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Significance and Diagnostic Accuracy of Resistive Index in Predicting Malignant Ovarian Masses Keeping Histopathology as Gold Standard

Journal of Gandhara Medical and Dental Sciences
OBJECTIVE This study aimed to determine the significance and diagnostic accuracy of the resistive index (RI) in predicting malignancy in ovarian masses, using histopathology as the gold standard. METHODOLOGY This prospective study was conducted at
Sana Iqbal, Anam Safdar, Shandana khan
doaj   +1 more source

Association of levels of serum inhibin b and follicle-stimulating hormone with testicular vascularity, volume, and echotexture in children with undescended testes

Journal of Indian Association of Pediatric Surgeons, 2017
Aims: The aim of our study was to assess the association between reproductive hormones (inhibin B [inh B], follicle-stimulating hormone [FSH]) with testicular volume, echogenicity, and blood flow (resistive index [RI]) in children with undescended testis
Abhishek Chinya, Simmi K Ratan, Satish K Aggarwal, Anju Garg, T K Mishra   +4 more
doaj   +1 more source

Topological constraints on magnetic field relaxation

, 2012
Magnetic field relaxation is determined by both the field's geometry and its topology. For relaxation processes, however, it turns out that its topology is a much more stringent constraint. As quantifier for the topology we use magnetic helicity and test
Brandenburg, Axel, Candelaresi, Simon
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source