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Bulletin du cancer, 1995
Drug resistance is a frequent clinical event, induced by more than one mechanism. It is intrinsic and/or acquired by tumoral cell population. But the failure of chemotherapy is also associated to intratumoral drug incorporation and altered drug and/or cell metabolism.
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Drug resistance is a frequent clinical event, induced by more than one mechanism. It is intrinsic and/or acquired by tumoral cell population. But the failure of chemotherapy is also associated to intratumoral drug incorporation and altered drug and/or cell metabolism.
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Efavirenz: resistance and cross-resistance.
International journal of clinical practice. Supplement, 1999Resistant strains, the major cause of treatment failure in the management of HIV infection, evolve whenever virus replication is incompletely suppressed by drug therapy. In such cases, genotypic analysis of proviral DNA or phenotypic analysis of viral isolates or recombinant molecular clones can provide useful information for the clinician. With regard
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