Results 151 to 160 of about 4,279,285 (309)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Resolution 45-11: Municipal ID Program

, 2011
In this Resolution, the City Council of the City of Richmond recognizes the importance and potential benefit that a Municipal Identification (ID) program would offer, and directs City staff to review the draft Municipal ID Ordinance, to propose ...
City Council of the City of Richmond [CA]
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Overcoming Artificial Structures in Resolution-Enhanced Hi-C Data by Signal Decomposition and Multi-Scale Attention. [PDF]

Adv Sci (Weinh)
Li Q, Li KY, Nicoletti C, Tsui SK, Puri PL, Cao Q, Yip KY.   +6 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Resolution 718-02: Reuniting the Sanchez Family

, 2002
In this Resolution, File No. 021691, the Board of Supervisors of the City and County of San Francisco urges the Immigration and Naturalization Service (INS) to do what is necessary to reunite the Sanchez family and urges the INS and Department of Justice
Board of Supervisors of the City and County of San Francisco [CA]
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Super-Resolution-Assisted Farmland Boundary Extraction from Medium-Resolution Satellite Image: A Real-ESRGAN and YOLO Segmentation Framework. [PDF]

Sensors (Basel)
Yu J, Yin H, Huang X, Liu J, Yang S, Zeng B, Zhang J, Wang X, Xiong B.   +8 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Resolution 14-0683: Policy to Decline Detainer Requests

, 2014
In this Resolution, the Board of Commissioners of Fulton County urges the Sheriff of Fulton County to decline Immigration and Customs Enforcement (ICE) detainer requests unless specific criteria is ...
Board of Commissioners of Fulton County [GA]
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Design of a New FAIMS Device With Replaceable Accessories and Analysis of the Impact of Spacing. [PDF]

Rapid Commun Mass Spectrom
Wu Y, Li Y, Shi Y, Du X, Li H.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source