Results 171 to 180 of about 4,444,880 (307)

Deep Learning for Protein Secondary-Structure Segmentation in Intermediate-Resolution Cryo-EM Maps: A Resolution-Stratified Benchmark Dataset and Controlled Evaluation. [PDF]

ACS Omega
Pial MER, Dehan FN, Sazzed S.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Topical Ciprofloxacin for Non-Perforated Acute Otitis Media: A Randomized Controlled Trial. [PDF]

Laryngoscope Investig Otolaryngol
Ghadban E, Boutros T, Romani D, Dunya G.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Temporal resolution shapes inferred higher-order interactions and information representation in neural population activity: A data-driven approach using minimally complex models. [PDF]

PLoS One
Jangjoo F.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Low-affinity exchangeable probes for super-resolution and long-term fluorescence imaging. [PDF]

Chem Sci
Klymchenko AS, Pelletier R, Didier P.
europepmc   +1 more source

Resolution unfolding with limits imposed by statistical experimental errors.

, 1977
A typical form of the resolution equation is derived by considering the physical measurement of an energy dependent spectrum. It is shown that the information contained in a data set may be expressed by writing the spectrum as a linear combination of a ...
Lang, DW
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Impact of depth-of-interaction and spatially-variant point-spread-function model on the performance of ultra-high resolution brain PET. [PDF]

Phys Med Biol
Zeng T, Najmaoui Y, Zhang J, Volpi T, Fontaine K, Chemli Y, Hu Y, Gallezot JD, Sun C, Lu Y, El Fakhri G, Carson RE, Marin T.   +12 more
europepmc   +1 more source