Results 51 to 60 of about 3,407,911 (288)

Direct numerical investigations of dilute dispersed flows in homogeneous turbulence

, 2012
The motivation for the present work is to investigate particle-laden turbulent flows using accurate numerical simulations. In the present work, the carrier phase is modeled using direct numerical simulations (DNS) and the particles are tracked in a ...
Karnik, Aditya U.
core   +1 more source

From κ to χ: evaluating hygroscopicity-based mixing state estimates with a particle-resolved model [PDF]

Atmospheric Chemistry and Physics
Aerosol mixing state strongly influences how particles interact with clouds, radiation, and atmospheric chemistry, but it remains difficult to quantify from routine observations.
Y. Liu, J. Wang, N. Riemer
doaj   +1 more source

Efficient methods for particle-resolved direct numerical simulation

, 2023
In the present chapter we focus on the fundamentals of non-grid-conforming numerical approaches to simulating particulate flows, implementation issues and grid convergence vs. available reference data. The main idea is to avoid adapting the mesh (and - as much as possible - the discrete operators) to the time-dependent fluid domain with the aim to ...
Uhlmann, Markus, Derksen, Jos, Wachs, Anthony, Wang, Lian-Ping, Moriche, Manuel   +4 more
openaire   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Analysis of Heat Transfer in Dense Suspensions by Particle Resolved Numerical Simulations

, 2016
International audienceThe simulation particulate flows with resolved scale particles is considered. In particular, the heat exchange between particles and surrounding fluid is investigated in terms of Nusselt number, particle density, solid fraction ...
Vincent, Stéphane, Thiam, E. Ibrahima, Simonin, Olivier, Climent, Éric, Masi, Enrica   +4 more
core   +2 more sources

The impact of aerosol mixing state on immersion freezing: insights from classical nucleation theory and particle-resolved simulations [PDF]

Atmospheric Chemistry and Physics
Immersion freezing, initiated by ice-nucleating particles (INPs) in supercooled aqueous droplets, plays an important role in the formation of ice crystals within clouds.
W. Tang, S. Arabas, J. H. Curtis, D. A. Knopf, M. West, N. Riemer   +5 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

ADAPTIVE QUASICONTINUUM SIMULATION OF ELASTIC-BRITTLE DISORDERED LATTICES

Acta Polytechnica CTU Proceedings, 2017
The quasicontinuum (QC) method is a computational technique that can efficiently handle atomistic lattices by combining continuum and atomistic approaches.
Karel Mikeš, Milan Jirásek
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

A high-efficiency pseudo-homogeneous model for coupled heat and moisture transfer during ventilation drying of maize grain piles

Case Studies in Thermal Engineering
To accurately predict heat and moisture transfer during ventilation drying in maize storage facilities, a computationally efficient pseudo-homogeneous model (PHM) was developed. By incorporating porosity distributions from particle-resolved computational
Wenlei Liu, Rufang Guo, Xulong Zhang, Panqi Wang, Ranran Wang   +4 more
doaj   +1 more source