Results 121 to 130 of about 9,486 (287)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Transition mechanisms in hypersonic wind-tunnel nozzles: a methodological approach using global linear stability analysis

Flow
Base-flow computations and stability analyses are performed for a hypersonic wind tunnel nozzle at a Mach number of 6. Isothermal and adiabatic wall boundary conditions are investigated, and moderate stagnation conditions are used to provide ...
Hugo Lemarquand, Mathieu Lugrin, Cédric Content, Clément Caillaud, Sébastien Esquieu, Denis Sipp   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Solution of the axismmetric plane thermoelasticity problem for a polar-orthotropic disc of variable thickness in the rotating thermal field by Volterra integral equation of the second kind

Журнал Белорусского государственного университета: Математика, информатика, 2017
With the help of linear Volterra integral equation of the second kind the solution of the axisymmetric plane thermoelasticity problem for a polar-orthotropic disk of variable thickness in the rotating thermal field is generally given.
Uladzimir V. Karalevich, Dmitrij G. Medvedev   +1 more
doaj  

Resolving thromboinflammation [PDF]

Blood, 2021
Stephen P. McAdoo, Neeraj Dhaun
openaire   +2 more sources

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

The Complexity of Resolvent Resolved

, 1993
The concept of a resolvent of a prime ideal was originally introduced by J.F. Ritt along with the notion of a characteristic set. The motivation for studying resolvents comes from its connections with the birational isomorphisms that describe ...
Giovanni Gallo, Bud Mishra
core  

Spectral Approach to Fractional Power of Operator and Its Matrix Approximation

Fractal and Fractional
This article is devoted to constructing the fractional powers of operators and their matrix approximations. A key feature of this study is the use of a spectral approach that remains applicable even when the base operator does not generate a semigroup ...
Vassili N. Kolokoltsov, Elina L. Shishkina   +1 more
doaj   +1 more source