Results 71 to 80 of about 883 (266)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
MATEC Web of Conferences, 2016 This work is devoted to get Jost solution by the method of variation of parameters and properties of this Jost solution of a boundary value problem (BVP) depending on an hyperbolic eigenparameter.
Aygar Yelda
doaj +1 more source
Journal of Lipid ResearchSphingolipids are increasingly recognized as critical regulators of inflammation and cell fate decisions, with metabolites such as ceramide and sphingosine 1-phosphate exerting contrasting effects on cell survival and proliferation. In macrophages, this balance is especially important, given their central role in host defense, pathogenesis and wound ...
Nathan F. Chiappa +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Molecular analysis of resolving immune responses in uveitis
Clinical and Experimental Immunology, 1999 SUMMARYTo identify the cellular immune processes underlying intra-ocular inflammation, aqueous humour was obtained at cataract surgery from 22 patients with clinically inactive uveitis and 24 patients with age-related cataract. mRNA expression for the cytokines IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12, interferon-gamma (IFN-γ), transforming growth factor ...
P I, Murray +3 more
openaire +3 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Wilson loops in ABJM theory reloaded
Journal of High Energy PhysicsWe present a new technique for computing supersymmetric Wilson loops in the ABJM theory via supersymmetric localization, valid for arbitrary values of the rank of the gauge group N and the Chern-Simons level k.
Bercel Boldis +2 more
doaj +1 more source
Fixed Point Theory and Applications, 2010 The main purpose of this paper is to introduce and study a new class of generalized nonlinear set-valued quasi-variational inclusions system involving (A,η)-accretive mappings in Banach spaces.
Mao Ming Jin, An Jian Xu, Hong-Gang Li
doaj +1 more source