Results 81 to 90 of about 883 (266)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Analysis of Retinoids and Carotenoids: Problems Resolved and Unsolved [PDF]
The Journal of Nutrition, 2004 Progress in nutritional biochemistry has always depended on progress in analysis of nutrients. Animal growth assays were fundamentally important in the discovery and initial isolation of the fat-soluble vitamins. Chromatography, initially introduced by Tswett for separation of plant pigments (including carotenoids), quickly became indispensable for ...
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Resolvent analysis of a swimming foil
This study employs resolvent analysis to explore the dynamics and coherent structures in the boundary layer of a foil that swims via a travelling wave undulation. A modified NACA foil shape is used together with undulatory kinematics to represent fish-like bodies at realistic Reynolds numbers ($ \mathit{Re} = 10,000 $ and $ \mathit{Re} = 100,000 $) in ...
Massey, Jonathan M. O. +3 more
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Global and target analysis of time-resolved spectra
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2004 In biological/bioenergetics research the response of a complex system to an externally applied perturbation is often studied. Spectroscopic measurements at multiple wavelengths are used to monitor the kinetics. These time-resolved spectra are considered as an example of multiway data.
van Stokkum, I.H.M. +2 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Scalable resolvent analysis for three-dimensional flows
Journal of Computational PhysicsResolvent analysis is a powerful tool for studying coherent structures in turbulent flows. However, its application beyond canonical flows with symmetries that can be used to simplify the problem to inherently three-dimensional flows and other large systems has been hindered by the computational cost of computing resolvent modes. In particular, the CPU
Ali Farghadan +2 more
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Algorithms for Solving System of Extended General Variational Inclusions and Fixed Points Problems
Abstract and Applied Analysis, 2012 We introduce a new system of extended general nonlinear variational inclusions with different nonlinear operators and establish the equivalence between the aforesaid system and the fixed point problem.
Narin Petrot, Javad Balooee
doaj +1 more source