Results 91 to 100 of about 22,026,600 (288)

Resolving versus non-resolving sphingolipid dynamics during macrophage activation: a time-resolved metabolic analysis

Journal of Lipid Research
Sphingolipids are increasingly recognized as critical regulators of inflammation and cell fate decisions, with metabolites such as ceramide and sphingosine 1-phosphate exerting contrasting effects on cell survival and proliferation. In macrophages, this balance is especially important, given their central role in host defense, pathogenesis and wound ...
Nathan F. Chiappa, Nidhi Lal, Edward A. Botchwey   +2 more
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Wilson loops in ABJM theory reloaded

Journal of High Energy Physics
We present a new technique for computing supersymmetric Wilson loops in the ABJM theory via supersymmetric localization, valid for arbitrary values of the rank of the gauge group N and the Chern-Simons level k.
Bercel Boldis, Gregory P. Korchemsky, Alessandro Testa   +2 more
doaj   +1 more source

A Hybrid Proximal Point Three-Step Algorithm for Nonlinear Set-Valued Quasi-Variational Inclusions System Involving (A,η)-Accretive Mappings

Fixed Point Theory and Applications, 2010
The main purpose of this paper is to introduce and study a new class of generalized nonlinear set-valued quasi-variational inclusions system involving (A,η)-accretive mappings in Banach spaces.
Mao Ming Jin, An Jian Xu, Hong-Gang Li
doaj   +1 more source

Molecular analysis of resolving immune responses in uveitis

Clinical and Experimental Immunology, 1999
SUMMARYTo identify the cellular immune processes underlying intra-ocular inflammation, aqueous humour was obtained at cataract surgery from 22 patients with clinically inactive uveitis and 24 patients with age-related cataract. mRNA expression for the cytokines IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12, interferon-gamma (IFN-γ), transforming growth factor ...
P I, Murray, C D, Clay, C, Mappin, M, Salmon   +3 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Resolvent Estimates for Elliptic Quadratic Differential Operators

, 2013
Sharp resolvent bounds for nonselfadjoint semiclassical elliptic quadratic differential operators are established, in the interior of the range of the associated quadratic ...
Hitrik, Michael, Lund University., Sjoestrand, Johannes, Viola, Joseph Anthony,   +3 more
core   +1 more source

Analysis of Retinoids and Carotenoids: Problems Resolved and Unsolved [PDF]

The Journal of Nutrition, 2004
Progress in nutritional biochemistry has always depended on progress in analysis of nutrients. Animal growth assays were fundamentally important in the discovery and initial isolation of the fat-soluble vitamins. Chromatography, initially introduced by Tswett for separation of plant pigments (including carotenoids), quickly became indispensable for ...
openaire   +2 more sources