Results 71 to 80 of about 4,036,910 (348)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

A local defect resonance for linear and nonlinear ultrasonic thermography [PDF]

, 2014
An efficient wave-defect interaction is the key to a high thermal response of flaws in ultrasonic thermography. To selectively enhance defect vibrations a concept of local defect resonance is developed and applied to ultrasonic activation of defects ...
Solodov, I., Rahammer, M., Busse, G.
core   +1 more source

Structural Properties of Human IAPP Dimer in Membrane Environment Studied by All-Atom Molecular Dynamics Simulations

Scientific Reports, 2017
The aggregation of human islet amyloid polypeptide (hIAPP) can damage the membrane of the β-cells in the pancreatic islets and induce type 2 diabetes (T2D). Growing evidences indicated that the major toxic species are small oligomers of IAPP.
Na Liu, Mojie Duan, Minghui Yang
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Deep Cerebellar Nuclei Segmentation via Semi-Supervised Deep Context-Aware Learning from 7T Diffusion MRI

IEEE Access, 2020
Deep cerebellar nuclei are a key structure of the cerebellum that are involved in processing motor and sensory information. It is thus a crucial step to accurately segment deep cerebellar nuclei for the understanding of the cerebellum system and its ...
Jinyoung Kim, Remi Patriat, Jordan Kaplan, Oren Solomon, Noam Harel   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Ultra-short echo time cardiovascular magnetic resonance of atherosclerotic carotid plaque [PDF]

, 2010
Background Multi-contrast weighted cardiovascular magnetic resonance (CMR) allows detailed plaque characterisation and assessment of plaque vulnerability.
Sonia Nielles-Vallespin, Nielles-Vallespin, S, Firmin, DN, Chan, Cheuk F, Keenan, Niall G, Mary N Sheppard, Gatehouse, Peter, Chan Cheuk F, Firmin David N, Gatehouse, P, Keenan, NG, Sheppard, MN, Boyle, JJ, Peter Gatehouse, Chan, CF, Sheppard Mary N, Boyle Joseph J, Joseph J Boyle, Niall G Keenan, Nielles-Vallespin, Sonia, Boyle, Joseph J, Sheppard, Mary N, Pennell, Dudley J, Pennell, DJ, Pennell Dudley J, Gatehouse Peter, Dudley J Pennell, Nielles-Vallespin Sonia, David N Firmin, Cheuk F Chan, Keenan Niall G, Firmin, David N   +31 more
core   +1 more source

Automated cardiovascular magnetic resonance image analysis with fully convolutional networks

Journal of Cardiovascular Magnetic Resonance, 2017
BackgroundCardiovascular resonance (CMR) imaging is a standard imaging modality for assessing cardiovascular diseases (CVDs), the leading cause of death globally.
Wenjia Bai, Matthew Sinclair, G. Tarroni, O. Oktay, Martin Rajchl, G. Vaillant, A. Lee, N. Aung, E. Lukaschuk, M. Sanghvi, F. Zemrak, K. Fung, J. Paiva, V. Carapella, Young Jin Kim, Hideaki Suzuki, Bernhard Kainz, P. Matthews, Steffen Erhard Petersen, S. Piechnik, S. Neubauer, Ben Glocker, D. Rueckert   +22 more
semanticscholar   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source