Results 71 to 80 of about 2,008,958 (317)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Assessing dimerisation degree and cooperativity in a biomimetic small-molecule model by pulsed EPR [PDF]

, 2015
AG acknowledges a postgraduate fellowship by the EPSRC funded doctoral training centre ‘integrated magnetic resonance’. BEB is grateful for an EaStCHEM Hirst Academic Fellowship by the School of Chemistry, St Andrews, and funding from the People ...
Bode, Bela Ernest, Slawin, Alexandra Martha Zoya, Giannoulis, A., Cordes, D. B., Ackermann, K., Ackermann, Katrin, Giannoulis, Angeliki, Cordes, David Bradford, Slawin, A. M. Z., Bode, B. E.   +9 more
core   +1 more source

ralucaru/Evection-Resonance-SUP v1.0.0 [PDF]

, 2020
Supplemental Materials: Tidal Evolution of the Evection Resonance/Quasi-Resonance and the Angular Momentum of the Earth-Moon ...
Robin M. Canup, Raluca Rufu
core   +1 more source

Deep Cerebellar Nuclei Segmentation via Semi-Supervised Deep Context-Aware Learning from 7T Diffusion MRI

IEEE Access, 2020
Deep cerebellar nuclei are a key structure of the cerebellum that are involved in processing motor and sensory information. It is thus a crucial step to accurately segment deep cerebellar nuclei for the understanding of the cerebellum system and its ...
Jinyoung Kim, Remi Patriat, Jordan Kaplan, Oren Solomon, Noam Harel   +4 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Function arising from second order approximations to the effective resonance integral. [PDF]

, 1965
A function K(θ,a1,aλ,x*0), which occurs in the evaluation of second order approximations to the effective resonance integral, is investigated. Various approximations to this function are given for a range of parameters appropriate to resonance ...
Pollard, JP, McKay, MH
core  

Improving the efficiency and accuracy of cardiovascular magnetic resonance with artificial intelligence-review of evidence and proposition of a roadmap to clinical translation [PDF]

Background Cardiovascular magnetic resonance (CMR) is an important imaging modality for the assessment of heart disease; however, limitations of CMR include long exam times and high complexity compared to other cardiac imaging modalities.
Wang, Yu, Zhang, Qiang, Fotaki, Anastasia, Prieto, Claudia, Doneva, Mariya, Wetzl, Jens, Ghadimi, Sona, Epstein, Frederick H, Delfino, Jana G, O'Regan, Declan P   +9 more
core   +1 more source

Structural Properties of Human IAPP Dimer in Membrane Environment Studied by All-Atom Molecular Dynamics Simulations

Scientific Reports, 2017
The aggregation of human islet amyloid polypeptide (hIAPP) can damage the membrane of the β-cells in the pancreatic islets and induce type 2 diabetes (T2D). Growing evidences indicated that the major toxic species are small oligomers of IAPP.
Na Liu, Mojie Duan, Minghui Yang
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Logical stochastic resonance with a coulomb-coupled quantum-dot rectifier [PDF]

, 2015
The authors gratefully acknowledge financial support from the European Union (FPVII, 2007-2013) under Grant Agreement No. 256959 NANOPOWER and Grant Agreement No. 318287 LANDAUER.Noise is mostly considered to be an adverse factor in electronics.
Hartmann, F., Worschech, L., Pfeffer, P., Hoefling, S., Kamp, M.   +4 more
core   +1 more source