Results 51 to 60 of about 2,012,511 (304)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Sensitivity-Enhanced SPR Sensor Based on Graphene and Subwavelength Silver Gratings

open access: yesNanomaterials, 2020
A novel surface plasmon resonance (SPR) sensor with graphene and subwavelength gratings is proposed to improve the sensing performance. A series of numerical analyses were performed to investigate the effect of structural parameters on the sensing ...
Lu Kong   +5 more
doaj   +1 more source

Portable Non-Destructive Magnetic Resonance Sensor for Assessing the Aging Status of Silicon Rubber Insulators

open access: yesNanomaterials, 2022
Silicone rubber insulators (SRIs) are widely used in high-voltage power grids. Due to high-voltage fields and harsh environmental conditions, SRIs eventually deteriorate with use in the power grid, decreasing their insulating performance and operational ...
Pan Guo   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

open access: yesFEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain   +11 more
wiley   +1 more source

Fluorine in silicate glasses: A multinuclear nuclear magnetic resonance study [PDF]

open access: yes, 1992
Anhydrous nepheline, jadeite, and albite glasses doped with F as well as hydrous F-containing haplogranitic glasses were investigated using 19F combined rotation and multiple-pulse spectroscopy; 19F → 29Si cross-polarization/magic angle spinning (MAS ...
Merwin, Lawrence   +5 more
core   +1 more source

Angle-Resolved Plasmonic Properties of Single Gold Nanorod Dimers

open access: yesNano-Micro Letters, 2014
Through wet-chemical assembly methods, gold nanorods were placed close to each other and formed a dimer with a gap distance ~1 nm, and hence degenerated plasmonic dipole modes of individual nanorods coupled together to produce hybridized bonding and ...
Jian Wu   +6 more
doaj   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan   +14 more
wiley   +1 more source

Ex-vivo HRMAS of adult brain tumours: metabolite quantification and assignment of tumour biomarkers [PDF]

open access: yes, 2010
Background: High-resolution magic angle spinning (HRMAS) NMR spectroscopy allows detailed metabolic analysis of whole biopsy samples for investigating tumour biology and tumour classification.
B Bell   +29 more
core   +2 more sources

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