Results 71 to 80 of about 83,540 (268)

Superconducting Microwave Resonator Arrays for Submillimeter/Far-infrared Imaging [PDF]

open access: yes, 2012
Superconducting microwave resonators have the potential to revolutionize submillimeter and far-infrared astronomy, and with it our understanding of the universe.
Noroozian, Omid
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Performance of a Modified Negative Branch Unstable Resonator

open access: yes, 2007
Far field deployment of high power chemical oxygen iodine laser (COIL) affords optimally adapted resonator architectures. Such resonators shall enable high brightness operation.
Grünewald, Karin   +4 more
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Embedded optical microfiber coil resonator

open access: yes, 2007
The embedding of an optical microfiber coil resonator in Teflon is demonstrated. Resonances in excess of 9dB and Q-factors greater than 6000 have been observed.
Brambilla, Gilberto, Xu, Fei
core  

Low insertion loss modulator based on a vertically coupled photonic crystal resonator

open access: yes, 2012
We experimentally demonstrate a simple but more efficient technique to modulate and multiplex multiple WDM channels. Our design is based on a bus waveguide vertically coupled to multiple Photonic Crystal (PhC) resonator, each of which modulates an ...
Reed, G T   +11 more
core   +1 more source

Tunable Mid-Infrared Graphene Plasmonic Cross-Shaped Resonator for Demultiplexing Application

open access: yesApplied Sciences, 2020
In this study, a tunable graphene plasmonic filter and a two-channel demultiplexer are proposed, simulated, and analyzed in the mid-infrared (MIR) region.
Somayyeh Asgari, Tapio Fabritius
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

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