Results 91 to 100 of about 2,704,412 (312)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Remote Sensing, 2018 This work presents a new methodology to estimate the motion-induced standard deviation and related turbulence intensity on the retrieved horizontal wind speed by means of the velocity-azimuth-display algorithm applied to the conical scanning pattern of a
Miguel A. Gutiérrez-Antuñano +3 more
doaj +1 more source
Addressing Minority Health Disparities in Richmond: Results from a Health Needs Assessment of a Southside Community [PDF]
, 2020 Background: Evidence shows the effectiveness of integrating community health workers (CHWs) into care models serving high-risk patients to reduce emergency department (ED) use, increase primary care use, and address adverse social determinants of health
Arauz, MA, Nixon +2 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Scientific ReportsLignite has emerged as a critical material in contemporary energy portfolios, particularly in electricity generation. However, this work explores lignite’s potential beyond conventional uses, exploring on its energy conversion applications.
P. Gopinathan +11 more
doaj +1 more source
Supporting Decisions: Understanding natural resource management assessment techniques [PDF]
Report to the Land and Water Resources Research and Development Corporation. This document presents a review of NRM decision support techniques. It draws upon previous studies in the fields of management science, operations research, environmental ...
Darla Hatton MacDonald +2 more
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Offshore wind resource assessment off the coast of Daejeong, Jeju Island using 30-year wind estimates. [PDF]
Sci Rep, 2022 Kim B, Lee K, Ko K, Choi J.
europepmc +1 more source
ASSESSING IMPACTS OF ENVIRONMENTAL CHANGE ON ABORIGINAL PEOPLE: AN ECONOMIC EXAMINATION OF SUBSISTENCE RESOURCE USE AND VALUE [PDF]
The report describes the research design, data collection and preliminary analysis of an economic assessment of non-timber resource use by Aboriginal People in Northwest Saskatchewan.
Adamowicz, Wiktor L. +4 more
core +1 more source