Results 111 to 120 of about 2,732,747 (312)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Compensation for Natural Resource Injury: An Emerging Federal Framework [PDF]
This paper provides an overview of the emerging "Superfund" natural resource damage assessment and compensation framework and a review of several economic and legal issues that are likely to affect the ability of the framework to achieve its objectives ...
Dower, Roger C., Scodari, Paul F.
core +1 more source
Defective neural motor speech mappings as a source for apraxia of speech : evidence from a quantitative neural model of speech processing [PDF]
, 2011 This unique resource reviews research evidence pertaining to best practice in the clinical assessment of established areas such as intelligibility and physiological functioning, as well as introducing recently developed topics such as conversational ...
Kroger, Bernd, Lowit, Anja, Miller, N.
core
Wind and solar resource assessment and prediction using Artificial Neural Network and semi-empirical model: case study of the Colombian Caribbean region. [PDF]
Heliyon, 2021 Silvera OC, Chamorro MV, Ochoa GV.
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Supporting Decisions: Understanding natural resource management assessment techniques [PDF]
Report to the Land and Water Resources Research and Development Corporation. This document presents a review of NRM decision support techniques. It draws upon previous studies in the fields of management science, operations research, environmental ...
Darla Hatton MacDonald +2 more
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Asia Pacific Journal of Health ManagementBackground: Assessing health technology is a vital tool for determining whether interventions should be continued or stopped. Delivering efficient medical services in remote tribal, hilly regions demands careful planning to maximize limited resources ...
Amit Kumar Mittal +6 more
doaj
Frontiers in WaterGroundwater is vital for agriculture in semi-arid regions like Kongwa District, where surface water is scarce and rainfall unstable. Despite its significance, detailed knowledge on groundwater distribution in such areas is often lacking, hindering ...
Faida Zacharia +2 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source