Results 131 to 140 of about 135,773 (264)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Lunar Resource Assessment: an Industry Perspective [PDF]
, 1992 The goals of the U.S. space program are to return to the Moon, establish a base, and continue onward to Mars. To accomplish this in a relatively short time frame and to avoid the high costs of transporting materials from the Earth, resources on the Moon ...
Altenberg, B. H. +2 more
core +1 more source
New resource assessment characterization factors for rare earth elements: applied in NdFeB permanent magnet case study [PDF]
Purpose Rare earth elements (REEs) are among the most critical raw materials with a high supply risk. Despite their criticality, REEs are not covered by any resource Life Cycle Impact Assessment (LCIA) Methods. The main purpose of the current study is to
Lafhaj, Zoubeir +2 more
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Supporting Decisions: Understanding natural resource management assessment techniques [PDF]
Report to the Land and Water Resources Research and Development Corporation. This document presents a review of NRM decision support techniques. It draws upon previous studies in the fields of management science, operations research, environmental ...
Stefan Hajkowicz +2 more
core
Rethinking assessment for the science modules in the first year nursing programme: Final project report [PDF]
, 2011 This project evaluated an innovative assessment tool that was developed to provide evidence that students were developing science-informed competence for nursing.
Hipkins, Rose +7 more
core
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Formative and summative assessment and the notion of constructive alignment [PDF]
, 2005 This paper discusses the different perceptions of first year accounting students about their tutorial\ud activities and their engagements in assessment.
Muldoon, Nona, Lee, Chrisann
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source