Results 121 to 130 of about 2,732,747 (312)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Sustaining rural livelihoods in fragile environments: Resource endowments or policy interventions? [PDF]
This paper primarily assesses the status of rural livelihoods in fragile environments with diverse resource endowments and policy interventions. The objective was to examine the effectiveness of resource enhancing policy interventions like watershed ...
John Sussan +3 more
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Devolution of Environmental and Natural Resource Management in the Philippines: Analytical and Policy Issues [PDF]
This paper is an assessment of the constraints and opportunities for capturing the gains from the devolution of environmental and natural resource (ENR) management and for engendering a more sustainable ENR management system in the Philippines.
Manasan, Rosario G.
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
The Use of Multi-Source Feedback as a Human Resource Management Tool [PDF]
The article is devoted to the Multiple Source Assessment method as a process of Human Resource Management. Several aspects related to the definition of this method and others concerning its importance, purpose, application and feedback are presented ...
Anca-Maria Stanculescu, Bogdan Georgescu
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Piscataqua Region Environmental Planning Assessment [PDF]
, 2010 The Piscataqua Region Environmental Planning Assessment (PREPA) was conducted to document the current status of environmental planning efforts and land use regulations for each of the 42 New Hampshire municipalities and 10 Maine municipalities (city and ...
Sowers, Derek
core +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Risk Assessment for National Natural Resource Conservation Programs [PDF]
This paper reviews the risk assessments prepared by the U.S. Department of Agriculture (USDA) in support of regulations implementing the Conservation Reserve Program (CRP) and Environmental Quality Incentives Program (EQIP).
Powell, Mark, Wilson, James
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