Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Wind and solar resource assessment and prediction using Artificial Neural Network and semi-empirical model: case study of the Colombian Caribbean region. [PDF]
Silvera OC, Chamorro MV, Ochoa GV.
europepmc +1 more source
A Remote Laser Mass Spectrometer for Lunar Resource Assessment [PDF]
The use of lasers as a source of excitation for surface mass spectroscopy has been investigated for some time. Since the laser can be focused to a small spot with intensity, it can vaporize and accelerate atoms of material.
Deyoung, R. J., Williams, M. D.
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Ocean wave energy resource assessment-- hotspots, exceedance-persistance, and predictability : a thesis presented in partial fulfilment of the requirements for the degree of Master of Applied Science in Natural Resource Engineering at Massey University [PDF]
Ocean wave energy conversion is evolving towards commercial viability. Succinct resource assessment is essential to the conversion of wave energy for grid supply electrical generation. The ability to differentiate potential wave energy locations by means
Frazerhurst, James Edward
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Background: Assessing health technology is a vital tool for determining whether interventions should be continued or stopped. Delivering efficient medical services in remote tribal, hilly regions demands careful planning to maximize limited resources ...
Amit Kumar Mittal +6 more
doaj
Groundwater is vital for agriculture in semi-arid regions like Kongwa District, where surface water is scarce and rainfall unstable. Despite its significance, detailed knowledge on groundwater distribution in such areas is often lacking, hindering ...
Faida Zacharia +2 more
doaj +1 more source
Supporting Decisions: Understanding natural resource management assessment techniques [PDF]
Report to the Land and Water Resources Research and Development Corporation. This document presents a review of NRM decision support techniques. It draws upon previous studies in the fields of management science, operations research, environmental ...
Darla Hatton MacDonald +2 more
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