Results 71 to 80 of about 9,284,406 (331)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Empowerment of Fisherfolk through Entrepreneurial Capacity Building of Self-help Groups in Marine Sector

International Journal of Bio-Resource and Stress Management
The investigation was conducted during July, 2019 to March, 2022 at ICAR-Central Marine Fisheries Research Institute (CMFRI) in Ernakulam District, Kerala, India to empower Scheduled Caste (SC) fisherfolk by promoting entrepreneurial capacity building ...
V. P. Vipinkumar, N. Aswathy, Reshma Gills, C. Ramachandran, J. Jayasankar, P. S. Swathilekshmi, S. Shinoj, P. A. Vikas, R. Vidya, A. R. Anuja , P. V. Athira, P. S. Sary, K. V. Binitha, T. V. Ambrose   +13 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

NATURAL RESOURCES ASSESSMENT [PDF]

, 2000
The purpose of this report is to summarize the scientific work that was performed to evaluate and assess the occurrence and economic potential of natural resources within the geologic setting of the Yucca Mountain area. The extent of the regional areas of investigation for each commodity differs and those areas are described in more detail in the major
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Optimizing the use of Indigenous high ash bituminous coal for sustainable pulverized coal injection and efficient energy transfer

Scientific Reports
The beneficiation of indigenous high ash bituminous coal is crucial for optimizing its suitability for Pulverized Coal Injection (PCI) in the steel industry.
Amit Karmakar, P. Gopinathan, T. Subramani, Amiya S. Naik, Manoj Kr. Sethi, M. Santosh, Pinaki Sarkar, Pradip Kr. Banerjee   +7 more
doaj   +1 more source

Addressing Minority Health Disparities in Richmond: Results from a Health Needs Assessment of a Southside Community [PDF]

, 2020
Background: Evidence shows the effectiveness of integrating community health workers (CHWs) into care models serving high-risk patients to reduce emergency department (ED) use, increase primary care use, and address adverse social determinants of health
Arauz, MA, Nixon, Blanco, MPH, Robert A., Jackson, MA, Shanteney   +2 more
core   +1 more source

Irrigated Agriculture and the Cost Recovery Principle of Water Services: Assessment and Discussion of the Case of the Guadalquivir River Basin (Spain) [PDF]

, 2018
The Cost Recovery Principle (CRP) is considered by the European Union (EU) water policy as a substantial requirement for economic efficiency, transparency, fairness, and sustainability in the use of water resources.
Expósito García, Alfonso
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Enhancing access to underutilized ground water potential for improving livelihoods and conflict reduction in Kagera Sub-Basin, Tanzania

Frontiers in Water
Groundwater is a crucial resource for global populations and economies, particularly in developing countries where water scarcity is a growing concern.
Estella Mgala, Joel Nobert, Edmund B. Mabhuye, Brown Gwambene   +3 more
doaj   +1 more source