Results 91 to 100 of about 976 (208)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Huckleberry Habitat and Its Influence on Two Small Populations of Grizzly Bears (Ursus arctos)

Ecology and Evolution
Huckleberries (Vaccinium spp.) are a nutritionally important food to grizzly bears (Ursus arctos) in interior, western North America. They provide sugar‐rich calories in late summer and fall prior to denning. We developed a resource selection function of
Justin E. Teisberg, Wayne F. Kasworm, Michael F. Proctor, Thomas G. Radandt, Jennifer K. Fortin‐Noreus, Hilary S. Cooley   +5 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Ensembled evaluations of habitat suitability for prioritizing lesser prairie‐chicken conservation

Ecosphere
Populations of lesser prairie‐chickens (Tympanuchus pallidicinctus, hereafter “prairie‐chickens”) in the Mixed‐Grass Prairie Ecoregion of the southern Great Plains have been projected to go extinct in the next 100 years unless targeted conservation ...
Morgan J. Solomon, Kent A. Fricke, Carter Kruse, Lance B. McNew   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Management implications of habitat selection by whooping cranes (Grus americana) on the Texas coast

Ecosphere
Effective habitat management for rare and endangered species requires a thorough understanding of their specific habitat requirements. Although machine learning models have been increasingly used in the analyses of habitat use by wildlife, the primary ...
Sarah E. Lehnen, Steven E. Sesnie, Matthew J. Butler, Aaron T. Pearse, Kristine L. Metzger   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

False negatives – A false problem in studies of habitat selection?

Ideas in Ecology and Evolution, 2010
Habitat use and resource selection studies based on presence-only data often use simulated locations as a benchmark for comparison with locations where a species has been observed.
André Desrochers, Eliot J. B. Mcintire, Steve G. Cumming, Josh Nowak, Sapna Sharma   +4 more
doaj  

Abundant resources compensate for the uneven distribution of ungulates in desert grassland

Frontiers in Plant Science
IntroductionStrategically managing livestock grazing in arid regions optimizes land use and reduces the damage caused by overgrazing. Controlled grazing preserves the grassland ecosystem and fosters sustainability despite resource limitations.
Xiaowei Gou, Xiaowei Gou, Atsushi Tsunekawa, Mitsuru Tsubo, Fei Peng, Yunxiang Cheng   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source