Results 41 to 50 of about 276,633 (266)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

In vitro screening and in vivo evaluation of antiparasitic phytochemicals against Cryptocaryon irritans in pompano, Trachinotus ovatus

Journal of the World Aquaculture Society, 2022
Cryptocaryon irritans, one of the most devastating holotrichous ciliated protozoans, causes massive economic losses in the pompano, Trachinotus ovatus, mariculture industries.
Wei‐Wei Mao, Zi‐Chen Zhao, Gui‐Hua Li, Wei‐Liang Guo, Ze‐Hao Ding, Shi‐Feng Wang, Yun Sun, Zhen‐Jie Cao, Jian‐Long Li, Yong‐Can Zhou   +9 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Trait responses, nonconsumptive effects, and the physiological basis of Helicoverpa armigera to bat predation risk

Communications Biology
Predation reduces the population density of prey, affecting its fitness and population dynamics. Few studies have connected trait changes with fitness consequences in prey and the molecular basis and metabolic mechanisms of such changes in bat-insect ...
Yingying Liu, Yang Geng, Man Si, Dan Zhu, Zhenglanyi Huang, Hanli Yin, Hao Zeng, Jiang Feng, Tinglei Jiang   +8 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Mechanical Constitutive and Seepage Theoretical Model of Water Storage Media Based on Fractional Derivative

Geofluids, 2022
Using an abandoned underground goaf in coal mines as water reservoirs has been successfully applied for protecting mine water resources in western China. The water storage media are composed of broken rock masses and the voids between the rock masses. It
Lujun Wang, Yang Wu, Xiaoqian Zhu, Peng Li, Zhiguo Cao, Huan Yang   +5 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Leaf functional metabolic traits reveal the adaptation strategies of larch trees along the R/B ratio gradient at the stand level

Scientific Reports
Light is crucial for understory sapling regeneration, and understanding leaf functional traits (LFT) is key to saplings’ adaptation to different light conditions. Currently, how LFT vary with light quality heterogeneity is not well understood. This study
Xiaoqian Song, Zhonghua Zhang, Haiyan Huang, Xin Guan, Lu Jin, Yu Shi, Wenjie Wang, Zhonghua Tang   +7 more
doaj   +1 more source