Results 51 to 60 of about 276,633 (266)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Water table-temperature synergy drives maximal growth and photosynthesis in subtropical Sphagnum palustre under moderate regimes

BMC Plant Biology
Background Sphagnum mosses serve as a crucial carbon sequestration component in peatland ecosystems, and their carbon assimilation capacity is largely governed by growth rates under the interaction of the water table and temperature regulation.
Lian Liu, BeiBei Huang, GuangQi Lai, WenChang Zhou, Nan Wu, Qiang Xiao, Lin Wu, Jia Xiong   +7 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Diet and environmental factors jointly drive the gut microbiome, resistome, and virulome of urban bats

npj Biofilms and Microbiomes
The coexistence and horizontal transfer of antibiotic resistance genes (ARGs) and virulence factor genes (VFGs) carried by urban wildlife represent an emerging form of biological pollution, constituting a significant threat to public health.
Long Huang, Ying-Ting Pu, Yan-Hui Zhao, Xiao-Yu Sun, Yue Zhu, Ya-Ping Lu, Hai-Xia Leng, Jiang Feng, Long-Ru Jin, Ke-Ping Sun   +9 more
doaj   +1 more source

Mechanism and Application of High-efficiency Collector MY-1 for Lead-zinc Separation

Kuangchan zonghe liyong
[Objective]The main useful minerals in a mine (Guangxi) are jamesonite and marmatite. When using conventional collector, lime is needed to separate lead from zinc at high alkaline condition, and the selectivity of agent is poor in the presence of high ...
Xiong CHEN, Mingfei HE, Hao BU, Youyou TANG, Min JIA   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Impact of rainfall on root water uptake in two characteristic species of coal mining subsidence areas in Northwest China [PDF]

PeerJ
Clarifying how plants utilize water in coal mining subsidence zones is essential for grasping plant-soil dynamics and guiding ecological rehabilitation.
Ruimin He, Haoyan Wei, Mingzhe Lei, Jiping Niu, Zhenguo Xing, Shi Chen, Da Lei, Gang Liu, Min Guo, Yang Lei, Min Li   +10 more
doaj   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Ultrasound-assisted extraction and antioxidant activity of polyphenolic compounds from three different fruit form of Lonicera caerulea L.

Scientific Reports
This study compared different forms of Lonicera caerulea L. fruit (fresh berries, dried berries, freeze-dried powder) to assess their suitability for storage and transport by analyzing their polyphenolic compounds content via ultrasound-assisted ...
Mei Yang, Yao Liu, Xinyu Huang, Shangnan Zhou, Xiaoxue Wei, Yuedong Lv, Chunjian Zhao, Dewen Li, Ying Liu   +8 more
doaj   +1 more source