Results 71 to 80 of about 2,301,842 (265)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Headedness and structure of Xitsonga compound words
LiteratorCompound words, formed by combining two or more morphemes, play a significant role in Xitsonga’s lexicon. This study employs a descriptive qualitative approach to examine how the head and modifier(s) interact to contribute to the overall structure and ...
Respect Mlambo +2 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Nicknames among Swati clans: A socio-cultural analysis
LiteratorNicknames are common in African societies. In Swati families, the use of nicknames is widespread and almost every member of a family possesses one. The nicknames are given to people in addition to their personal names from a young age until adulthood ...
Muzi Matfunjwa +2 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Respect, Self-Respect, and Self-Knowledge
The MonistAbstract Knowledge and respect exhibit a puzzling self-other asymmetry: Self-respect generates an imperative to know oneself, but as the objectionability of paternalism and privacy violations illustrate, respect for others can require that we avoid acquiring, or making use of, knowledge we have about them.
openaire +2 more sources
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Cogent Arts & HumanitiesThis study investigates the strategic deployment of conditional sentences in political discourse, exploring how diverse types of conditionals function as persuasive mechanisms to shape voter perceptions, construct political narratives, and mobilise ...
Innocent Zitha +2 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source