Results 91 to 100 of about 1,093,438 (391)

Reverse Methanogenesis and Respiration in Methanotrophic Archaea

Archaea, 2017
Anaerobic oxidation of methane (AOM) is catalyzed by anaerobic methane-oxidizing archaea (ANME) via a reverse and modified methanogenesis pathway. Methanogens can also reverse the methanogenesis pathway to oxidize methane, but only during net methane ...
P. Timmers, C. Welte, J. Koehorst, C. Plugge, M. Jetten, A. Stams   +5 more
semanticscholar   +1 more source

Factors controlling spatio-temporal variation in carbon dioxide efflux from surface litter, roots, and soil organic matter at four rain forest sites in the eastern Amazon [PDF]

, 2007
[1] This study explored biotic and abiotic causes for spatio-temporal variation in soil respiration from surface litter, roots, and soil organic matter over one year at four rain forest sites with different vegetation structures and soil types in the ...
Aragao, L. E. O. C., Braga, A., da Costa, A. C. L., de Almeida, S. S., de Athaydes, J., Goncalves, P. H. L., Malhi, Y., Meir, P., Metcalfe, D. B., Williams, M.   +9 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Decomposition of coarse woody debris in a long-term litter manipulation experiment: A focus on nutrient availability [PDF]

, 2018
The majority of above-ground carbon in tropical forests is stored in wood, which is returned to the atmosphere during decomposition of coarse woody debris.
Gora, Evan M., Sayer, Emma J., Tanner, Edmund V. J., Turner, Benjamin L.   +3 more
core   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Sirt3 Promotes Chondrogenesis, Chondrocyte Mitochondrial Respiration and the Development of High-Fat Diet-Induced Osteoarthritis in Mice [PDF]

, 2020
Shouan Zhu, Elise L. Donovan, Dawid Mąkosa, Padmaja Mehta-D’souza, Anita Jopkiewicz, Albert Batushansky, Dominic Cortassa, Aaron D. Simmons, Erika Barboza Prado Lopes, Michael Kinter, Timothy M. Griffin   +10 more
openalex   +1 more source

KATP Channel Openers Have Opposite Effects on Mitochondrial Respiration Under Different Energetic Conditions [PDF]

, 2008
Mitochondrial (m) KATP channel opening has been implicated in triggering cardiac preconditioning. Its consequence on mitochondrial respiration, however, remains unclear. We investigated the effects of two different KATP channel openers and antagonists on
Camara, Amadou K.S., Eells, Janis T., Heinen, André, Henry, Michele M., Riess, Matthias L., Stowe, David F.   +5 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Preliminary analysis of gut microbiome characteristics in children with obstructive sleep apnea hypopnea syndrome

Frontiers in Neurology
ObjectiveTo analyze the characteristic changes in the gut microbiome in children with obstructive sleep apnea-hypopnea syndrome (OSAHS) and to investigate the relationship between the gut microbiome and polysomnography (PSG) results.MethodsChildren ...
Zhihui Wang, Zhihui Wang, Luting Zhou, Yanyu He, Xueyun Xv, Meng Lv, Zhen Zhang, Fengqian Wang, Shuqi Wang, Yuqing Wang   +9 more
doaj   +1 more source

MicroRNA‐7‐5p induces cell growth inhibition, cell cycle arrest and apoptosis by targeting PAK2 in non‐small cell lung cancer

FEBS Open Bio, 2019
MicroRNAs (miR) are known to be critical regulators in tumor progression. miR‐7‐5p was reported to be involved in several cancers, including glioblastoma, cervical cancer, and melanoma, but its prognostic value and biological function in non‐small‐cell ...
Qin Li, Xingping Wu, Lin Guo, Jiaxin Shi, Jiashu Li   +4 more
doaj   +1 more source