Results 81 to 90 of about 854,331 (290)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Nomogram for Predicting Efficacy and Prognosis After Chemotherapy for Advanced NSCLC

The Clinical Respiratory Journal
Purpose One major issue is the therapeutic effect following chemotherapy for non–small cell lung cancer (NSCLC). Although numerous risk factors have been identified and novel therapies have been developed, improving patient overall survival (OS) remains ...
Jiaying Gao, Yandong Nan, Gang Liu, Shihong Zhao, Huanqing Xiong, Yifeng Wang, Faguang Jin   +6 more
doaj   +1 more source

Study Effect of Azithromycin and Doxycycline in Mucus Producing and Inflammatory Signaling Pathways of Allergic Asthma

Iranian Journal of Allergy, Asthma and Immunology, 2022
Asthma is a respiratory disease; involving millions of people worldwide. The main cause of asthma is allergy and immune response dysregulation. The effects of azithromycin and doxycycline as asthma-controlling drugs were evaluated in this study.
Zhen Wang, Lihong Xin, Wen Zhang
doaj  

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

The influence of soil communities on the temperature sensitivity of soil respiration [PDF]

, 2018
Soil respiration represents a major carbon flux between terrestrial ecosystems and the atmosphere, and is expected to accelerate under climate warming.
AM Makarieva, B Bond-Lamberty, B Bond-Lamberty, B Bond-Lamberty, CD Koven, CE Hicks Pries, CJ Mikan, CO Nielsen, CP Giardina, E Dorrepaal, EA Davidson, EA Davidson, G Yvon-Durocher, H Chen, H Ferris, H Petersen, J Kozlowski, J Laybourn, J Yang, JA Subke, JC Carey, JF Exbrayat, JH Brown, JH Brown, JS Clein, JW Raich, K Karhu, KB Suttle, LE Rustad, M Nie, M Reichstein, MA Bradford, MD Mahecha, MJI Briones, MP Thakur, N Eisenhauer, N Fierer, P Hogberg, PM Cox, R Aerts, R Klekowski, RB Ehnes, RM Sibly, SL Chown, T Fenchel, TC Balser, TD Meehan, TW Crowther, X Xu   +48 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Research on the treatment of Pseudomonas aeruginosa pneumonia in children by macrolide antibiotics

Open Medicine, 2015
To observe a therapeutic effect of macrolide antibiotics in children with Pseudomonas aeruginosa pneumonia. Fifty-four cases of children with Pseudomonas aeruginosa pneumonia were randomly divided into an observation group (n=30) and a control group (n ...
Huang Xu-qiang, Deng Li, Lu Gen, He Chun-hui, Wu Pei-qiong, Xie Zhi-wei, Aqeel Ashraf Muhammad   +6 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

A Review of Drug Therapy of Lung Cancer with Interstitial Lung Disease

Chinese Journal of Lung Cancer, 2020
Interstitial lung disease (ILD) is a risk factor for lung cancer. Patients with lung cancer associated with ILD (LC-ILD) often appear clinically. During the treatment of LC-ILD, there is a risk of causing acute exacerbation or even death in the treatment
Yanning WANG, Yujie ZHOU, Liyun MIAO
doaj   +1 more source

Gas low pressure low flow rate metering system Patent [PDF]

, 1971
Flowmeters for sensing low fluid flow rate and pressure for application to respiration rate ...
Fagot, R. J., Mcdonald, R. T., Roman, J. A.   +2 more
core   +1 more source