Results 61 to 70 of about 854,331 (290)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Distinguish active tuberculosis with an immune-related signature and molecule subtypes: a multi-cohort analysis

Scientific Reports
Background: Distinguishing latent tuberculosis infection (LTBI) from active tuberculosis (ATB) is very important. This study aims to analyze cases from multiple cohorts and get the signature that can distinguish LTBI from ATB.
Qingqing Shan, Yangke Li, Kun Yuan, Xiao Yang, Li Yang, Jian-Qing He   +5 more
doaj   +1 more source

Interleukin-4 and interferon gamma in bronchial remodeling in asthma patients with cold airway hyperresponsiveness

Бюллетень сибирской медицины
Interleukin-4 (IL-4) and interferon gamma (IFNγ) are key participants in the polarization of the immune response toward Th1 or Th2 types in bronchial asthma.
A. B. Pirogov, A. G. Prikhodko, N. A. Pirogova, D. A. Gassan, D. E. Naumov, J. M. Perelman   +5 more
doaj   +1 more source

MicroRNA‐7‐5p induces cell growth inhibition, cell cycle arrest and apoptosis by targeting PAK2 in non‐small cell lung cancer

FEBS Open Bio, 2019
MicroRNAs (miR) are known to be critical regulators in tumor progression. miR‐7‐5p was reported to be involved in several cancers, including glioblastoma, cervical cancer, and melanoma, but its prognostic value and biological function in non‐small‐cell ...
Qin Li, Xingping Wu, Lin Guo, Jiaxin Shi, Jiashu Li   +4 more
doaj   +1 more source

Seasonal dynamics of soil respiration and nitrogen mineralization in chronically warmed and fertilized soils [PDF]

, 2011
Although numerous studies have examined the individual effects of increased temperatures and N deposition on soil biogeochemical cycling, few have considered how these disturbances interact to impact soil C and N dynamics.
Contosta, Alexandra R., Cooper, Andrew B., Frey, Serita D.   +2 more
core   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Preliminary analysis of gut microbiome characteristics in children with obstructive sleep apnea hypopnea syndrome

Frontiers in Neurology
ObjectiveTo analyze the characteristic changes in the gut microbiome in children with obstructive sleep apnea-hypopnea syndrome (OSAHS) and to investigate the relationship between the gut microbiome and polysomnography (PSG) results.MethodsChildren ...
Zhihui Wang, Zhihui Wang, Luting Zhou, Yanyu He, Xueyun Xv, Meng Lv, Zhen Zhang, Fengqian Wang, Shuqi Wang, Yuqing Wang   +9 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

T lymphocyte subsets and mitochondrial index predict outcomes in advanced non small cell lung cancer therapy

Scientific Reports
Currently, accessible objective indicators for predicting the prognosis and treatment outcomes of non-small cell lung cancer (NSCLC) are lacking. This study investigates the potential of T lymphocyte subsets and mitochondrial biomarkers as predictors of ...
Zhengming Huang, Chiqing Ying, Dan Zhu
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source