Results 21 to 30 of about 395,235 (313)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Genotyping and refractory risk factors of mycoplasma pneumoniae pneumonia in Suzhou, China

BMC Infectious Diseases
Objective To investigate the genotyping and drug resistance of Mycoplasma pneumoniae (MP) epidemic strains in children and analyze the risk factors for refractory Mycoplasma pneumoniae pneumonia (RMPP).
Wenjing Gu, Zhuxia Li, Enze Han, Xin Kuai, Shenghao Hua, Shan Gao, Zhengrong Chen, Li Huang, Yuqing Wang, Chuangli Hao, Xinxing Zhang   +10 more
doaj   +1 more source

Prevalence and biomarkers in metabolic syndrome

Ожирение и метаболизм, 2021
The prevalence of metabolic syndrome (MS) has a worldwide tendency to increase and depends on many components, which explains the complexity of diagnostics and approaches to the prevention and treatment of this pathology.
O. Y. Kytikova, M. V. Antonyuk, T. A. Kantur, T. P. Novgorodtseva, Y. K. Denisenko   +4 more
doaj   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

INTERRELATION OF CHANGES IN CONCENTRATION OF LEPTIN AND ω-3 FAMILY ACIDS IN THE PLACENTA AT THE REACTIVATION OF CYTOMEGALOVIRUS INFECTION IN THE III TRIMESTER OF HUMAN PREGNANCY

Acta Biomedica Scientifica, 2017
A gas-chromatographic study was conducted of the content of essential polyunsaturated fatty acids of the ω-3 family: eicosapentaenoic and docosahexaenoic, an enzyme-linked immunosorbent assay of leptinin the homogenate of placental tissue in women who ...
N. A. Ishutina, M. T. Lutsenko, I. A. Andrievskaya, N. N. Dorofienko   +3 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

SNHG15 enhances cisplatin resistance in lung adenocarcinoma by affecting the DNA repair capacity of cancer cells

Diagnostic Pathology, 2023
Background Lung adenocarcinoma (LUAD) is a prevalent malignancy. SNHG15 has been demonstrated to be oncogenic in many kinds of cancers, however the mechanism of SNHG15 in LUAD cisplatin (DDP) resistance remains unclear. In this study, we demonstrated the
Yong Li, Hui-Qin Huang, Zheng-Hui Huang, Nan-Ding Yu, Xiang-Li Ye, Mei-Chen Jiang, Li-Min Chen   +6 more
doaj   +1 more source

Bronchial granulocytes in the development of epithelial destruction and oxidative lipid modification in patients with bronchial asthma with cold and osmotic airway hyperresponsiveness

Сибирский научный медицинский журнал, 2021
Free radical damage to the respiratory tract in patients with asthma leads to the destruction of the bronchial parenchyma and the generation of signaling molecules of inflammation by parenchymal cells.
A. B. Pirogov, A. G. Prikhodko, Ju. M. Perelman   +2 more
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source