Results 241 to 250 of about 196,983 (291)

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

Transcriptomic Analysis of the Amygdala in Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder Reveals Differentially Altered Metabolic Pathways. [PDF]

Schizophr Bull
Zhang X, Valeri J, Eladawi MA, Gisabella B, Garrett MR, Vallender EJ, McCullumsmith R, Pantazopoulos H, O'Donovan SM.   +8 more
europepmc   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Macrophage metabolic reprogramming by vanadium released from glucose-responsive bio-gel accelerates diabetic wound repair. [PDF]

Signal Transduct Target Ther
Li J, Li Z, Han L, Xu N, Jia J, Hu A, Chen Y, Liu C, Zhang X, Zhu W, Yu Y, Luo G.   +11 more
europepmc   +1 more source

Adipocyte NADH dehydrogenase reverses circadian and diet-induced metabolic syndrome. [PDF]

Nat Metab
Hepler C, Waldeck NJ, Weidemann BJ, Marcheva B, Chen YJ, Hecker J, Zhu Z, Nozawa R, Mastroni JV, Thorne AK, Reczek CR, Cedernaes J, Ramsey KM, Peek CB, Barish GD, Chandel NS, Bass J.   +16 more
europepmc   +1 more source

Smarca4 maintains mitochondrial homeostasis and energy metabolism during cardiac development. [PDF]

Cell Mol Life Sci
Park DD, Kim S, Boos A, Andrasch Y, Krieg L, Rottbauer W, Just S.   +6 more
europepmc   +1 more source

Thermal Cameras for Overnight Measuring of Respiration in a Clinical Setting. [PDF]

Sensors (Basel)
Alves R, van Meulen F, Overeem S, Janssen H, van Hirtum P, Zinger S, Stuijk S.   +6 more
europepmc   +1 more source

Symptom clustering of old adult dysphagic patient phenotypes by unsupervised machine learning using multidimensional characteristics: a cross-sectional study. [PDF]

BMC Geriatr
Zhang Y, Dai Y, Wang H, Gong Z, Cai J.
europepmc   +1 more source

Roles of Oxidative Phosphorylation and Fatty Acid Oxidation in Neuroinflammation Induced by Lipopolysaccharide in Hypothalamic Neuronal Cells. [PDF]

Int J Inflam
El-Hamri MA, Lahmouad M, Zerrouk J, El-Mernissi R, Hajji L, Makhathini KB, Khalki H, Abboussi O.   +7 more
europepmc   +1 more source