Results 201 to 210 of about 832,170 (284)
Abstract Microcytic anemia is among the most common hematological abnormalities in clinical practice and is usually attributable to iron deficiency, thalassemia traits, or anemia of inflammation. A small but clinically important subset of patients, however, has inherited disorders of iron metabolism or heme synthesis presenting with persistent ...
Alexandros Makis +2 more
wiley +1 more source
The Acid-Base Effects of Albumin in Sepsis: Reconciling the Stewart Physicochemical Approach with the Traditional Buffer-Base Paradigm. [PDF]
Orso D, Saro R, Della Rocca G.
europepmc +1 more source
ABSTRACT Background and Aims Meconium‐stained amniotic fluid (MSAF) is a common intrapartum finding associated with adverse perinatal outcomes. Comprehensive global estimates of its prevalence and determinants are lacking. This systematic review and meta‐analysis aimed to estimate the global pooled prevalence of MSAF and classify its associated factors.
Shervin Tabrizian +3 more
wiley +1 more source
Early prediction of multiple organ failure for sepsis patients based on machine learning algorithms
Abstract In recent years, there has been a notable rise in sepsis incidence leading to more multiple organ failure and higher mortality. The lack of effective treatments for sepsis highlights the importance of early prediction in preventing multiple organ failure. This study aimed to develop a model for the early prediction of multiple organ failure in
Runnan He +11 more
wiley +1 more source
Tracheal intubation in the critically ill: beyond the airway, toward hemodynamic precision. [PDF]
Prakash J +3 more
europepmc +1 more source
An Optimized Diagnostic Approach for Adults With Suspected Inherited Metabolic Disorders
A multidisciplinary strategy that integrates deep phenotyping with expert genetic interpretation substantially increases the likelihood of reaching a diagnosis in adults suspected of having an IMD. ABSTRACT Inherited metabolic disorders (IMDs) arise from defects in metabolic pathways essential for normal biochemical function.
Machteld M. Oud +12 more
wiley +1 more source
From Common Pathway to Divergent Diseases: Metabolic Aspects of Inborn Errors of CoA Biosynthesis
ABSTRACT Coenzyme A (CoA) biosynthesis is a conserved, dynamically regulated pathway essential for mitochondrial energy production, fatty acid oxidation, lipid biosynthesis and protein acylation. Biallelic variants in PANK2, PPCS, PPCDC, and COASY cause rare inborn errors of CoA biosynthesis, associated with markedly different clinical phenotypes ...
Ivano Di Meo +3 more
wiley +1 more source
Medium Chain Acyl‐CoA Dehydrogenase Deficiency; an Unexpected Cause of Neonatal Ketoacidosis
ABSTRACT Medium‐chain acyl‐CoA dehydrogenase deficiency (MCADD) classically presents with hypoketotic hypoglycaemia; however, this presentation is now rare following the introduction of newborn screening. While children with MCADD may produce some ketones, severe ketoacidosis has not been previously described.
Nazreen Kamarus Jaman +7 more
wiley +1 more source

