Results 41 to 50 of about 1,167,422 (304)

Extracorporeal Carbon Dioxide Removal Using a Renal Replacement Therapy Platform to Enhance Lung-Protective Ventilation in Hypercapnic Patients With Coronavirus Disease 2019-Associated Acute Respiratory Distress Syndrome

Frontiers in Medicine, 2020
Coronavirus disease 2019 (COVID-19)-associated acute respiratory distress syndrome (ARDS) is associated with high mortality. Lung-protective ventilation is the current standard of care in patients with ARDS, but it might lead to hypercapnia, which is ...
Faeq Husain-Syed, Faeq Husain-Syed, Faeq Husain-Syed, Horst-Walter Birk, Jochen Wilhelm, Jochen Wilhelm, Jochen Wilhelm, Jochen Wilhelm, Claudio Ronco, Claudio Ronco, V. Marco Ranieri, Bianka Karle, Stefan Kuhnert, Khodr Tello, Khodr Tello, Khodr Tello, Matthias Hecker, Matthias Hecker, Rory E. Morty, Rory E. Morty, Rory E. Morty, Rory E. Morty, Susanne Herold, Susanne Herold, Susanne Herold, Oliver Kehl, Hans-Dieter Walmrath, Hans-Dieter Walmrath, Werner Seeger, Werner Seeger, Werner Seeger, Werner Seeger, Werner Seeger, Werner Seeger, István Vadász, István Vadász, István Vadász   +36 more
doaj   +1 more source

Acute renal response to rapid onset respiratory acidosis.

Canadian Journal of Physiology and Pharmacology, 2011
Renal strong ion compensation to chronic respiratory acidosis has been established, but the nature of the response to acute respiratory acidosis is not well defined.
J. Ramadoss, R. Stewart, T. Cudd
semanticscholar   +1 more source

A Case of Biotinidase Deficiency in an Adult with Respiratory Failure in the Intensive Care Unit

Balkan Medical Journal, 2016
Background: Biotinidase deficiency (BD) is a rare, inherited autosomal recessive disorder that is treatable within childhood. We present a patient with pneumonia and respiratory acidosis who was not diagnosed with any systemic disorders; the patient was ...
Zerrin Demirtürk, Evren Şentürk, Abbas Köse, Perihan Ergin Özcan, Lütfi Telci   +4 more
doaj   +1 more source

MTO1 Mutations are Associated with Hypertrophic Cardiomyopathy and Lactic Acidosis and Cause Respiratory Chain Deficiency in Humans and Yeast

Human Mutation, 2013
We report three families presenting with hypertrophic cardiomyopathy, lactic acidosis, and multiple defects of mitochondrial respiratory chain (MRC) activities.
E. Baruffini, C. Dallabona, F. Invernizzi, J. W. Yarham, L. Melchionda, E. Blakely, E. Lamantea, C. Donnini, S. Santra, S. Vijayaraghavan, H. Roper, A. Burlina, R. Kopajtich, A. Walther, T. Strom, T. Haack, H. Prokisch, Robert W. Taylor, I. Ferrero, M. Zeviani, D. Ghezzi   +20 more
semanticscholar   +1 more source

BCS1L‐Associated Disease: 5′‐UTR Variant Shifts the Phenotype Towards Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the consequences of a pathogenic missense variant (c.838C>T; p.L280F) and a 5′‐UTR regulatory variant (c.‐122G>T) in BCS1L on disease pathogenesis and to understand how regulatory variants influence disease severity and clinical presentation.
Rotem Orbach, Nunziata Maio, Russell J. Butterfield, A. Reghan Foley, Sarah Silverstein, Yan Li, Katherine Chao, Tanya J. Lehky, Abigail Potticary, Tracey A. Rouault, Sandra Donkervoort, Carsten G. Bönnemann   +11 more
wiley   +1 more source

Effect of metabolic and respiratory acidosis on intracellular calcium in osteoblasts.

AJP - Renal Physiology, 2010
In vivo, metabolic acidosis {decreased pH from decreased bicarbonate concentration ([HCO(3)(-)])} increases urine calcium (Ca) without increased intestinal Ca absorption, resulting in a loss of bone Ca. Conversely, respiratory acidosis [decreased pH from
K. Frick, D. Bushinsky
semanticscholar   +1 more source

Glycolytic Enzyme HK2 Phosphorylates nSMase1 to Promote Astrocytic Exosomes Biogenesis Contributing to Acute Ischemic Stroke Injury

Advanced Science, EarlyView.
This study reveals that the glycolytic enzyme HK2 mediates hypoxia‐induced astrocytic exosome biogenesis by directly phosphorylating nSMase1. These astrocytic exosomes impair brain endothelial tight junctions. Astrocyte‐specific knockdown of HK2 reduces exosome release and alleviates brain injury after MCAO.
Chen Chen, YuWei Zhou, LongXiang Sheng, FangYing Mai, YuXuan Ding, ShiRan Hong, JiaXin Wu, JiaKai Pi, GuangMei Yan, YiJun Huang, JingJing Duan, Xuefeng Hua, Wei Yin   +12 more
wiley   +1 more source

Respiratory and metabolic acidosis correction with the ADVanced Organ Support system

Intensive Care Medicine Experimental, 2019
Background The lung, the kidney, and the liver are major regulators of acid-base balance. Acidosis due to the dysfunction of one or more organs can increase mortality, especially in critically ill patients.
Aritz Perez Ruiz de Garibay, John A. Kellum, Johannes Honigschnabel, Bernhard Kreymann   +3 more
doaj   +1 more source

Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype

Advanced Science, EarlyView.
This study demonstrates that biological acidosis, commonly observed in tumors and ischemic conditions, actively promotes the protonation of fatty acids, thereby facilitating the uptake of their neutral forms. Consequently, the preference for lipid metabolism in acid‐exposed cells does not arise from genetic reprogramming that prioritizes lipids as the ...
Sébastien Ibanez, Maria Virginia Giolito, Sultan Al‐Siyabi, Kristian Serafimov, Florine Laloux, Emeline Dierge, Léo Aubert, Céline Guilbaud, Selena Kaye, Paula Varon, Dorothée Marchand, Hanne Vlieghe, Emmanuel Hermans, Caroline Bouzin, Davide Brusa, Christiani Andrade Amorim, Barabara Pachikian, Yvan Larondelle, Cyril Corbet, Chantal Dessy, Olivier Feron   +20 more
wiley   +1 more source

Incidence and Risk Factors for Delirium among Mechanically Ventilated Patients in an African Intensive Care Setting: An Observational Multicenter Study

Critical Care Research and Practice, 2015
Aim. Delirium is common among mechanically ventilated patients in the intensive care unit (ICU). There are little data regarding delirium among mechanically ventilated patients in Africa.
Arthur Kwizera, Jane Nakibuuka, Lameck Ssemogerere, Charles Sendikadiwa, Daniel Obua, Samuel Kizito, Janat Tumukunde, Agnes Wabule, Noeline Nakasujja   +8 more
doaj   +1 more source