Results 71 to 80 of about 17,844 (219)

Carbonic anhydrase inhibitors in patients with respiratory failure and metabolic alkalosis: a systematic review and meta-analysis of randomized controlled trials

Critical Care, 2018
Background Metabolic alkalosis is common in patients with respiratory failure and may delay weaning in mechanically ventilated patients. Carbonic anhydrase inhibitors block renal bicarbonate reabsorption, and thus reverse metabolic alkalosis.
Bassem Y Tanios, Maryam O Omran, Carlos Noujeim, Tamara Lotfi, Samir S Mallat, Pierre K Bou-Khalil, Elie A Akl, Houssam S Itani   +7 more
doaj   +1 more source

Determinants of curvature constant (W’) of the power duration relationship under normoxia and hypoxia: the effect of pre-exercise alkalosis [PDF]

, 2017
Purpose This study investigated the effect of induced alkalosis on the curvature constant (W’) of the power-duration relationship under normoxic and hypoxic conditions.
Deb, S., Deb, S., Gough, L., Gough, L., McNaughton, L., McNaughton, L., Sparks, S.A., Sparks, S.A.   +7 more
core   +4 more sources

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

The Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet, Johannes Burtscher, Hannes Gatterer, Katharina Hüfner, Samuel Verges, Tadej Debevec, Martin Burtscher   +6 more
wiley   +1 more source

Vagal TRPV1 activation exacerbates thermal hyperpnea and increases susceptibility to experimental febrile seizures in immature rats

Neurobiology of Disease, 2018
Thermal hyperpnea, a pattern of breathing during hyperthermia that is characterized by an increase in tidal volume as well as breathing frequency, is known to lead to respiratory alkalosis.
Karlene T. Barrett, Arijit Roy, Keelin B. Rivard, Richard J.A. Wilson, Morris H. Scantlebury   +4 more
doaj   +1 more source

Maximal exercise at high altitude does not exacerbate inflammation in the human brain

The Journal of Physiology, EarlyView.
Abstract figure legend This study investigated arterial–internal jugular venous (IJV) exchange of cytokines in response to low‐intensity and maximal cycling exercise at sea level and following 6–8 days at 3800 m a.s.l. There was a shift towards net release of interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), monocyte chemoattractant protein‐1 (MCP‐1) and ...
Hannah G. Caldwell, Travis D. Gibbons, Connor A. Howe, Jack S. Talbot, Elliott J. Jenkins, L. Madden Brewster, Justin A. Monteleone, Jay M. J. R. Carr, Andrew R. Steele, Michael Stembridge, David B. MacLeod, Philip N. Ainslie   +11 more
wiley   +1 more source

Relationship of arterial and exhaled CO2 during elevated artificial pneumoperitoneum pressure for introduction of the first trocar. [PDF]

, 2011
The present study evaluated the correlation between arterial CO2 and exhaled CO2 during brief high-pressure pneumoperitoneum. Patients were randomly distributed into two groups: P12 group (n=30) received a maximum intraperitoneal pressure of 12mmHg ...
Afonso C. C. G. Machado, Bianca Marigliani, Fabiana Scarpelli, Glicia C. Azevedo, Gustavo P. S. Miguel, Joao-Luiz Azevedo, Jose F. Borborema, Linda Bernardes, Octavio H. M. Hypolito, Otavio C. Azevedo, Otavio M. Becker Junior, Susana A. Miyahira   +11 more
core   +1 more source

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Enhanced Na\u3csup\u3e+\u3c/sup\u3e/H\u3csup\u3e+\u3c/sup\u3e Exchange During Ischemia and Reperfusion Impairs Mitochondrial Bioenergetics and Myocardial Function [PDF]

, 2008
Inhibition of Na+/H+ exchange (NHE) during ischemia reduces cardiac injury due to reduced reverse mode Na+/Ca2+ exchange. We hypothesized that activating NHE-1 at buffer pH 8 during ischemia increases mitochondrial oxidation, Ca2+ overload, and reactive ...
Aldakkak, Mohammed, Camara, Amadou K.S., Heisner, James S., Spence, Marisha, Stowe, David F.   +4 more
core   +1 more source

Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?

Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley   +1 more source

Pedigree and Functional Analysis of Two Cryptic OTC Variants Causing Ornithine Transcarbamylase Deficiency in Two Unrelated Chinese Male Patients

Molecular Genetics &Genomic Medicine, Volume 14, Issue 5, May 2026.
Two unrelated Chinese male OTCD‐suspected patients harbored an OTC synonymous variant (c.663G>A, p.Lys221Lys) and a novel de novo in‐frame variant (c.756_761dupAGCAGC, p.Ala253_Ala254dup); minigene analysis confirmed the synonymous variant induces exon 6 skipping with 41 amino acid deletion (c.541_663del, p.Glu181_Lys221del).
Qingming Wang, Huimin Xiao, Fang Zhang, Hui Li, Juan Zhao, Haiming Yuan   +5 more
wiley   +1 more source