Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection [PDF]
Elife 10 (2021): e61700, 2020 In severe viral pneumonia, including Coronavirus disease 2019 (COVID-19), the viral replication phase is often followed by hyperinflammation, which can lead to acute respiratory distress syndrome, multi-organ failure, and death. We previously demonstrated that alpha-1 adrenergic receptor ($\alpha_1$-AR) antagonists can prevent hyperinflammation and ...
arxiv +1 more source
Surfactant function in neonates with respiratory distress syndrome [PDF]
, 1998 The function of pulmonary surfactant of a group of 14 preterm neonates (birth weight 907 +/- 60 g) who suffered from severe respiratory distress syndrome (RDS) and who had received exogenous bovine lipid extracted surfactant on the first day of life was ...
Griese, Matthias, Westerburg, Bettina
core +1 more source
Frontiers in Systems Biology, 2023 Introduction: Trauma is the leading cause of death in persons under the age of 45. Recovery in patients who survive initial trauma are frequently complicated by sequelae of injury that increases susceptibility to infection and inflammation.
Julia L. Larson +15 more
doaj +1 more source
Extracorporeal support for patients with acute respiratory distress syndrome. [PDF]
, 2014 Extracorporeal membrane oxygen (ECMO) has been used for many years in patients with life-threatening hypoxaemia and/or hypercarbia. While early trials demonstrated that it was associated with poor outcomes and extensive haemorrhage, the technique has ...
Finney, SJ
core +3 more sources
Successful Treatment of a Neonate with Idiopathic Persistent Pulmonary Hypertension with Inhaled Nitric Oxide via Nasal Cannula without Mechanical Ventilation. [PDF]
, 2012 We report a case study of a term neonate presenting with oxygen desaturation without respiratory distress or acidosis, despite receiving 100% oxygen through a nasal cannula.
Lakshminrusimha, Satyan +2 more
core +2 more sources
Continuous positive airway pressure (CPAP) to treat respiratory distress in newborns in low- and middle-income countries. [PDF]
, 2016 Severe respiratory distress is a serious complication common to the three major causes of neonatal mortality and morbidity (prematurity, intra-partum-related hypoxia and infections).
Ho JJ +3 more
core +2 more sources
Elastocapillary network model of inhalation [PDF]
Physical Review Research, 2, 043382 (2020), 2020 The seemingly simple process of inhalation relies on a complex interplay between muscular contraction in the thorax, elasto-capillary interactions in individual lung branches, propagation of air between different connected branches, and overall air flow into the lungs.
arxiv +1 more source
A Bayesian Machine Learning Approach for Estimating Heterogeneous Survivor Causal Effects: Applications to a Critical Care Trial [PDF]
, 2022 Motivated by the Acute Respiratory Distress Syndrome Network (ARDSNetwork) ARDS respiratory management (ARMA) trial, we developed a flexible Bayesian machine learning approach to estimate the average causal effect and heterogeneous causal effects among the always-survivors stratum when clinical outcomes are subject to truncation.
arxiv +1 more source
Estimation of Physical Activity Level and Ambient Condition Thresholds for Respiratory Health using Smartphone Sensors [PDF]
arXiv, 2021 While physical activity has been described as a primary prevention against chronic diseases, strenuous physical exertion under adverse ambient conditions has also been reported as a major contributor to exacerbation of chronic respiratory conditions.
arxiv
Alveolar fluid in acute respiratory distress syndrome promotes fibroblast migration: role of platelet-derived growth factor pathway [PDF]
, 2012 OBJECTIVES: Fibroblast migration is an initiating step in fibroproliferation; its involvement during acute lung injury and acute respiratory distress syndrome remains poorly understood. The aims of this study were: 1) to determine whether bronchoalveolar
A. Mailleux +10 more
core +3 more sources