Results 71 to 80 of about 1,819,855 (334)

Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.

New England Journal of Medicine, 2019
BACKGROUND The benefits of early continuous neuromuscular blockade in patients with acute respiratory distress syndrome (ARDS) who are receiving mechanical ventilation remain unclear.
M. Moss, David T. Huang, R. Brower, N. Ferguson, A. Ginde, M. Gong, C. Grissom, S. Gundel, D. Hayden, R. D. Hite, P. Hou, C. Hough, T. Iwashyna, Akram Khan, Kathleen D. Liu, D. Talmor, B. Thompson, C. Ulysse, D. Yealy, D. Angus   +19 more
semanticscholar   +1 more source

Clinical features and progression of acute respiratory distress syndrome in coronavirus disease 2019

medRxiv, 2020
Background: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in a cluster of coronavirus disease 2019 (COVID-19). We reported the clinical characteristics of COVID-19 patients with acute respiratory distress syndrome ...
Yanli Liu, Wenwu Sun, Jia Li, Liangkai Chen, Yujun Wang, Lijuan Zhang, Li Yu   +6 more
semanticscholar   +1 more source

The NSP5, ORF6 and NSP13 of SARS‐CoV‐2 Cooperate to Modulate Inflammatory Cell Death Activation

Advanced Science, EarlyView.
ZBP1 is capable of initiating a large cell death complex to induce programmed cell death during SARS‐CoV‐2 infection. However, SARS‐CoV‐2 can inhibit the activation of ZBP1‐mediated cell death by targeting key components of this complex. This suppression of ZBP1‐mediated cell death may account for the increased mortality observed in patients co ...
Huan Wang, Mengdi Liang, Jing Zhang, Hua Tong, Fenfen Zhang, Ying Liu, Pui Wang, Mengmeng Chang, Fei Han, Siwen Liu, Yongping Lin, Wenjun Song, Rajendra Karki, Peihui Wang, Honglin Chen, Yang Liu, Min Zheng   +16 more
wiley   +1 more source

Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. [PDF]

, 2009
PurposeDeposition of fibrin in the alveolar space is a hallmark of acute lung injury (ALI). Plasminogen activator inhibitor-1 (PAI-1) is an antifibrinolytic agent that is activated during inflammation. Increased plasma and pulmonary edema fluid levels of
Brady, Sandra, Curley, Martha AQ, Flori, Heidi, Matthay, Michael A, Sapru, Anil   +4 more
core   +2 more sources

Formal guidelines: management of acute respiratory distress syndrome

Annals of Intensive Care, 2019
Fifteen recommendations and a therapeutic algorithm regarding the management of acute respiratory distress syndrome (ARDS) at the early phase in adults are proposed.
L. Papazian, C. Aubron, L. Brochard, J. Chiche, A. Combes, D. Dreyfuss, J. Forel, C. Guérin, S. Jaber, A. Mekontso-Dessap, A. Mercat, J. Richard, D. Roux, A. Vieillard-Baron, H. Faure   +14 more
semanticscholar   +1 more source

Engineered Dual‐Function Antibody‐Like Proteins to Combat SARS‐CoV‐2‐Induced Immune Dysregulation and Inflammation

Advanced Science, EarlyView.
Engineered antibody‐like proteins block the SARS‐CoV‐2 spike protein from binding to host receptors and suppress immune overactivation through an MBL‐based scaffold. These dual‐function proteins effectively alleviate inflammation, complement activation, and lung injury, offering a promising therapeutic strategy against severe COVID‐19 and its ...
Yizhuo Wang, Chenwu Bai, Kerui Hou, Zhen Zhang, Ming Guo, Xin Wang, Fan Yang, Xin Liu   +7 more
wiley   +1 more source

How to perform open tracheal suction via an endotracheal tube [PDF]

, 2016
Rationale and key points Tracheal suction involves the removal of pulmonary secretions from the respiratory tract using negative pressure under sterile conditions.
Credland, Nicola
core   +1 more source

Phenotypes and personalized medicine in the acute respiratory distress syndrome

Intensive Care Medicine, 2020
Although the acute respiratory distress syndrome (ARDS) is well defined by the development of acute hypoxemia, bilateral infiltrates and non-cardiogenic pulmonary edema, ARDS is heterogeneous in terms of clinical risk factors, physiology of lung injury ...
M. Matthay, Y. Arabi, E. Siegel, L. Ware, L. Bos, P. Sinha, J. Beitler, K. Wick, M. Curley, J. Constantin, J. Levitt, C. Calfee   +11 more
semanticscholar   +1 more source

Inhalable Artificial Polymeric Nucleases Degrading Neutrophil Extracellular Trap‐DNAs and Alleviating Pulmonary Fibrosis

Advanced Science, EarlyView.
Pulmonary fibrosis (PF) is promoted by NETs that induce fibroblast activation. PEG‐PIm, a polymeric artificial DNase is reported that efficiently degrades NET‐DNA via phosphodiester bond hydrolysis. Inhalation of PEG‐PIm in a mouse PF model prevents fibroblast activation and fibrosis progression, offering a promising therapeutic strategy for NET ...
Yibo Du, Chenxu Zhu, Ruifeng Wang, Shi Chen, Chuang Li, Defang OuYang, Lixin Liu, Yongming Chen   +7 more
wiley   +1 more source

Guidelines on the management of acute respiratory distress syndrome

BMJ Open Respiratory Research, 2019
The Faculty of Intensive Care Medicine and Intensive Care Society Guideline Development Group have used GRADE methodology to make the following recommendations for the management of adult patients with acute respiratory distress syndrome (ARDS).
M. Griffiths, D. McAuley, G. Perkins, N. Barrett, B. Blackwood, Andrew J. Boyle, Nigel Chee, B. Connolly, P. Dark, S. Finney, Aemun Salam, J. Silversides, N. Tarmey, M. Wise, S. Baudouin   +14 more
semanticscholar   +1 more source