Results 31 to 40 of about 182,776 (202)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The effect of incorporating an arterial pH target during apnea test for brain death determination

Journal of Intensive Care, 2021
Background Persistent apnea despite an adequate rise in arterial pressure of CO2 is an essential component of the criteria for brain death (BD) determination. Current guidelines vary regarding the utility of arterial pH changes during the apnea test (AT).
Ibrahim Migdady, Moein Amin, Aaron Shoskes, Catherine Hassett, Sung-Min Cho, Pravin George, Alexander Rae-Grant   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Evaluation Electrical Activity of Diaphragm and Respiratory Drive During Successful Weaning of Traumatic Quadriplegic Patient by Neutrally Adjusted Ventilatory Assist Mode

Archives of Anesthesia and Critical Care, 2016
The case is 43 years old woman referred to emergency department of our hospital with quadriplegia and severe respiratory insufficiency due to C5-C6 injury after falling. She discharged from ICU after fixation of the lesion and successful weaning.
Atabak Najafi, Mohammad Reza Zeraati, Hamidreza Sharifnia   +2 more
doaj  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Pressão de oclusão das vias aéreas na avaliação do comando nervoso da respiração e da resposta muscular

Revista Portuguesa de Pneumologia, 1995
RESUMO: Os autores realçam a importância da avaliação do 'drive' respiratório e da eficácia da musculatura respiratória nos estudos da função pulmonar e descrevem as técnicas não invasivas para esta avaliação, que incluem a medida da pressà ...
A. Paes Cardoso, Alberto De Almeida, Alvaro Moreira Da Silva   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Respiratory pathology in vibroacoustic disease: 25 years of research O aparelho respiratório na doença vibroacústica: 25 anos de investigação

Revista Portuguesa de Pneumologia, 2007
Background: Respiratory pathology induced by low frequency noise (LFN,
Nuno A A Castelo Branco, José Reis Ferreira, Mariana Alves-Pereira   +2 more
doaj  

The invasive and non-invasive monitoring of inspiratory effort and drive during assisted mechanical ventilation

Annals of Intensive Care
Background: In patients with respiratory failure, assisted mechanical ventilation is often used after the initial acute phase to support patient’s respiratory activity, enhance oxygen exchange, and improve lung ventilation and perfusion.
Davide Chiumello, Alessandra Muscas, Simone Mancusi, Antonio Fioccola   +3 more
doaj   +1 more source