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Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure
Cell Host and Microbe, 2020 Proper management of COVID-19 mandates better understanding of disease pathogenesis. The sudden clinical deterioration 7–8 days after initial symptom onset suggests that severe respiratory failure (SRF) in COVID-19 is driven by a unique pattern of immune
Panagiotis Koufargyris +2 more
exaly +2 more sources
JAMA - Journal of the American Medical Association, 2020 This case series describes the proportion of awake, nonintubated inpatients with COVID-19 and hypoxemic respiratory failure requiring oxygen supplementation whose Pa o 2 increased ≥20% with prone positioning, and their respiratory status after resuming ...
Laurent Papazian
exaly +2 more sources
Indian Journal of Anaesthesia, 2003 Respiratory failure occurs due mainly either to lung failure resulting in hypoxaemia or pump failure resulting in alveolar hypoventilation and hypercapnia. Hypercapnic respiratory failure may be the result of mechanical defects, central nervous system depression, imbalance of energy demands and supplies and/or adaptation of central controllers ...
Praveen Kumar Neema
doaj +4 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The new SARS-CoV-2 pandemic leads to COVID-19 with respiratory failure, substantial morbidity, and significant mortality. Overactivation of the innate immune response is postulated to trigger this detrimental process.
Thor Ueland +2 more
exaly +2 more sources
American Journal of Respiratory and Critical Care Medicine, 2020 Rationale: The role of inspiratory effort still has to be determined as a potential predictor of noninvasive mechanical ventilation (NIV) failure in acute hypoxic de novo respiratory failure.
, Enrico Clini, Massimo Girardis
exaly +2 more sources
Use of nasal high flow oxygen during acute respiratory failure
Intensive Care Medicine, 2020 Nasal high flow (NHF) has gained popularity among intensivists to manage patients with acute respiratory failure. An important literature has accompanied this evolution. In this review, an international panel of experts assessed potential benefits of NHF
Nuttapol Rittayamai, , Byung Ju Kang
exaly +2 more sources
Neurological Respiratory Failure [PDF]
Diseases, 2018 West Nile virus infection in humans is mostly asymptomatic. Less than 1% of neuro-invasive cases show a fatality rate of around 10%. Acute flaccid paralysis of respiratory muscles leading to respiratory failure is the most common cause of death. Although
Mohan Rudrappa +2 more
doaj +3 more sources
Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2014 The main function of the lungs is to maintain the exchange between the pulmonary capillary and the air in the alveoli. By this way, the arteriel oxygen and carbondioxide tension remains constant.
Ezgi Ozyilmaz
doaj +3 more sources
Medicina, 2021 Background and Objectives The greatest challenge vaccines face is that of acceptance from the general population. Healthcare professionals’ (HCPs) recommendations have significant influence on general public vaccination behavior.
Athanasia Pataka +8 more
doaj +1 more source
The Lancet Respiratory Medicine, 2021 Background Awake prone positioning has been reported to improve oxygenation for patients with COVID-19 in retrospective and observational studies, but whether it improves patient-centred outcomes is unknown.
Stephan Ehrmann +182 more
semanticscholar +1 more source