Results 191 to 200 of about 1,064,228 (304)

Anti‐Apoptotic and Neurite‐Protective Nanomedicine Augments Embryonic Stem Cells‐Derived Retinal Ganglion Cell Transplantation in Glaucoma Recovery

Advanced Science, EarlyView.
Lithium‐epigallocatechin gallate nanoparticles (Li‐EGCG NPs) are co‐transplanted with embryonic stem cell‐derived retinal ganglion cells (ESC‐RGCs) to enhance cell survival and therapeutic efficacy in an acute pathological glaucomatous injury model. This synergistic approach protects RGC cells, preserves retinal structure and improves visual function ...
Moxin Chen, Xiaoyan Jiang, Yuanhui Wang, Zhaobin Luo, Yu Zhang, Siwei Liu, Rui Huang, Dandan Zhang, Zhimin Tang, Yahan Ju, Shaohui Pan, Ni Ni, Wei Feng, Yu Chen, Ping Gu   +14 more
wiley   +1 more source

Vascular dysfunction in COPD with and without chronic respiratory failure: a cross-sectional study. [PDF]

Front Physiol
Paneroni M, Simonelli C, Salvi B, Bertacchini L, Vitacca M, Venturelli M.   +5 more
europepmc   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Conformable Microelectrode Arrays Integrated with a Scoop‐Shaped Slide‐Well for Dynamic Electrophysiological Profiling of Patient‐Derived Cardiac Organoids

Advanced Science, EarlyView.
A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim, Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Jeongha Lee, Yoon Ji Jeong, Gyu Tae Park, Seongdo Jeong, Ki Won Hwang, Murim Choi, Jinhong Shin, Suck Won Hong, Jae Ho Kim   +12 more
wiley   +1 more source

Role of High flow nasal cannula in managing Type I respiratory failure in patients with neuromuscular disorders. [PDF]

BMC Pulm Med
Chakraborti A, Dutta S, Das M, Sonigra M, Khot MS, Wani AR.   +5 more
europepmc   +1 more source

The Role of Ionic Liquids at the Biological Interfaces in Bioelectronics

Advanced Science, EarlyView.
Ionic liquids (ILs) are highlighted as key artificial ionic materials that bridge biological ion‐based signaling and electronic devices. By understanding their composition, structure, function relationships, and mechanisms, ILs can advance from high performance electrolyte to core materials enabling integrated, multifunctional bioelectronics for ...
Yeong‐sinn Ye, Young Jin Jo, Ji Yeon Oh, Ju Yeon Jeong, Lili Guo, Tae‐il Kim   +5 more
wiley   +1 more source

Acute hYpErcapnic respiratory failure in The ICU: A multicenter prospective observational study - The YETI study. [PDF]

Ann Intensive Care
Dupuis C, Kamel T, Beyls C, Le Moal C, Garcon P, Goursaud S, Bodet-Contentin L, Ferré A, Guillot M, Gachet A, Noel T, Garin A, Argaud L, Bachoumas K, Persichini R, Jonas M, Nay MA, Cadoz C, Schortgen F, Guinard S, Foucault C, Labro G, Llitjos JF, Rouze A, Pham T, Hermann B, SRLF trial groups.   +26 more
europepmc   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

A Titin Knock-in model for Hereditary Myopathy with Early Respiratory Failure

Cetrangolo V, Gayathri SN, Marcello M, Salierno FG, Polishchuk E, Caremani M, Morotti I, Reconditi M, Sommella A, Sarparanta J, Linari M, Conte I, Nigro V, Savarese M, Udd B.   +14 more
europepmc   +1 more source

Awake Prone Positioning in Patients With COVID-19 Respiratory Failure: A Randomized Clinical Trial. [PDF]

JAMA Netw Open
Harrois A, Jouffroy R, Ayed S, Bruel C, Savale L, Devaux M, Maillet M, Cerf C, Lejealle C, Moreno CG, Levrat A, Gueneau R, Jouveshomme S, Bonnin P, De Rudnicki S, Damoisel C, Gille T, Cordel H, Meslin S, Bocquillon V, Noël N, Vieillard-Baron A, Teboul JL, Tran M, Werner M, Pichon J, Janbain A, Vicaut E, Duranteau J, PROVID Study Group.   +29 more
europepmc   +1 more source