Results 81 to 90 of about 3,032,232 (303)

Phenotyping exercise limitation of patients with Interstitial Fibrosing Lung Disease: the importance of exercise hemodynamics

Pulmonology
Introduction and objective Left-heart dysfunction and pulmonary vasculopathy are increasingly recognized as contributing factors of exercise capacity limitation in interstitial fibrosing lung disease (IFLD).
E. Panagiotidou, A. Βoutou, E. Fouka, D. Papakosta, E. Chatzopoulos, E. Sourla, A. Markopoulou, I. Kioumis, I. Stanopoulos, G. Pitsiou   +9 more
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Beta Agonist Lung Injury TrIal-2 (BALTI-2) trial protocol : a randomised, double-blind, placebo-controlled of intravenous infusion of salbutamol in the acute respiratory distress syndrome [PDF]

, 2011
Background: The Acute Respiratory Distress Syndrome (ARDS) is a common cause of respiratory failure in critically ill patients. Experimental studies suggest that treatment with beta agonists may be helpful in ARDS.
McCabe Chris, Young Duncan, Lamb, Sarah E, Young, Duncan S., McCabe, Chris, Gao, F, Perkins, Gavin D., Gates, S, Smith, F. Gao, Lamb, S. E., Chris McCabe, Fang Gao, Young, D, Duncan Young, Gao, Fang; id_orcid, Gao Fang, Perkins, GD, Young, Duncan, Gates, Simon, Lamb, Sarah, Sarah E Lamb, Gavin D Perkins, Perkins, Gavin D, Simon Gates, Lamb Sarah E, Gates Simon, McCabe, C, Perkins Gavin D, Lamb, SE   +28 more
core   +2 more sources

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Soluble IL-2R Levels Predict in-Hospital Mortality in COVID-19 Patients with Respiratory Failure

, 2021
Acute respiratory distress syndrome is the primary cause of death in patients with coronavirus disease 2019 (COVID-19) pneumonia. Our study aims to determine the association between serum markers and mortality in COVID-19 patients with respiratory ...
Su Hwan Lee, Young Sam Kim, Young Ae Kang, Ah Young Leem, Hye Jin Jang, Kyung Soo Chung, Jin Young Ahn, Ji Ye Jung, Moo Suk Park   +8 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

The successful treatment of hypercapnic respiratory failure with oral modafinil

, 2014
Helen Parnell,1 Ginny Quirke,1 Sally Farmer,1 Sumbo Adeyemo,2 Veronica Varney11Respiratory Department, 2Pharmacy Department, St Helier Hospital, Carshalton, Surrey, UKAbstract: Hypercapnic respiratory failure is common in advanced chronic obstructive ...
Farmer S, Parnell H, Quirke G, Adeyemo S, Varney V   +4 more
core  

Role of Respiratory Viruses in Severe Acute Respiratory Failure

Respiratory viruses are widespread in the community, affecting both the upper and lower respiratory tract. This review provides an updated synthesis of the epidemiology, pathophysiology, clinical impact, and management of severe respiratory viral ...
Mokrani, David, Timsit, Jean-François, Jean-François Timsit, David Mokrani   +3 more
core   +1 more source

Oro-nasal mask versus helmet in acute hypercapnic respiratory failure

, 2015
The choice of the interface for noninvasive ventilation (NIV) is a key factor in NIV success. We hypothesised that a new helmet specifically design to improve performance in hypercapnic patients would be clinically equivalent to a standard oronasal mask.
Musti M., Musti Muriel, Vaschetto, R, Bellone Andrea, Nava S., Mega, C, Scala, Raffaele, Forno, Manuela Del, S. Nava, GRASSI, MARIO, MUSTI, MURIEL ASSUNTA, Grassi M., Fasano, L, Fasano Luca, Pisani, L, FASANO, LUCA, A. Bellone, Vaschetto R., Cosentini, Roberto, Del Forno, M, MEGA, CHIARA, M. Musti, L. Pisani, Forno M. D., Navalesi, P, Cosentini, R, Musti, M, P. Navalesi, NAVA, STEFANO, Mega Chiara, Bellone, A, Del Forno Manuela, Navalesi, Paolo, Cosentini Roberto, Pisani L., Navalesi P., Scala Raffaele, M. D. Forno, Nava Stefano, Scala, R, Cosentini R., Navalesi P, Grassi Mario, Bellone A., C. Mega, Fasano L., L. Fasano, Mega C., Pisani Lara, Bellone, Andrea, Vaschetto Rosanna, Nava, S., PISANI, LARA, VASCHETTO, Rosanna, R. Scala, Scala R., M. Grassi, R. Cosentini   +57 more
core   +1 more source

Respiratory health and endotoxin: associations and modification by CD14/-260 genotype [PDF]

, 2011
Exposure to endotoxin has been associated with increased respiratory symptoms and decrements in lung function in occupational settings but little is known about the health effects of domestic exposure in adults.
Jarvis, D., Heederik, D., Svanes, C., M. Kogevinas, Dep IRAS, Norbäck D, D. Jarvis, J. P. Zock, Olivieri, Mario, Bakolis, I., Jarvis, D, C. M. Chen, on behalf of the Indoor group of the ECRHS, S. Guerra, D. Norback, G. Verlato, Norback, D., Bakolis I, Ramasamy, A, Svanes C, Jarvis D, Ramasamy A, Chen CM, J. Heinrich, Guerra, S., Chen, C.M., Chen, C. M., ?, ?, Castro-Giner, F., D. Heederik, null null, Kogevinas, M, Zock JP, Doekes, G., A. Nevalainen, VERLATO, Giuseppe, Nevalainen, A., HITEA Study Group (), Nevalainen, A, Chen, CM, Olivieri, M., Norbäck, D, Guerra, S, Svanes, C, Indoor Group of the ECRHS, I. Bakolis, Castro-Giner, F, Norbäck, Dan,, Kogevinas, M., Verlato, G., Heinrich, J, Risk Assessment of Toxic and Immunomodulatory Agents, Zock, JP, Bakolis, I, Olivieri, M, the Work Package 10 group of HITEA, Heinrich, J., Guerra S, Zock, J. P., Zock, J P, C. Svanes, Heinrich J, Kogevinas M, Chen, C M, Bakolis, I; id_orcid, A. Ramasamy, Verlato, G, Work Package 10 Group of HITEA, Nevalainen A, Doekes, G, Zock, J.P., G. Doekes, Doekes G, M. Olivieri, Heederick D, Ramasamy, A., Heederik, D, F. Castro-Giner   +77 more
core   +1 more source