Results 1 to 10 of about 5,815,326 (246)

Obtaining spirometric reference values when height is not available – comparison of alternative anthropometric measures

Pulmonology, 2020
Introduction Height is one of the variables used to derive reference values for respiratory function but it is not always available. To fulfil this need, different formulas are described in literature.Aim To understand which method best estimate height ...
N. China, D. Vaz, C. Martins, J. Gomes, I. Ladeira, R. Lima, M. Guimarães   +6 more
doaj   +3 more sources

The Impact of Monoclonal Antibodies on Airway Smooth Muscle Contractility in Asthma: A Systematic Review

Biomedicines, 2021
Airway hyperresponsiveness (AHR) represents a central pathophysiological hallmark of asthma, with airway smooth muscle (ASM) being the effector tissue implicated in the onset of AHR.
Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Giuseppina Bertorelli, Beatrice Ludovica Ritondo, Paola Rogliani, Alfredo Chetta   +6 more
doaj   +1 more source

Cryptogenic Fibrosing Pleuritis

European Journal of Case Reports in Internal Medicine, 2021
We report the case of a 46-year-old male patient who was referred for chest pain and bilateral pleural effusion. Despite treatment with antibiotics and steroids, the pleural effusion worsened over a few months until pulmonary function was halved.
Alessandra Anna Manco, Veronica Alfieri, Letizia Gnetti, Marina Aiello, Giuseppina Bertorelli, Maria Majori, Alfredo Chetta   +6 more
doaj   +1 more source

The COPD assessment test and the modified Medical Research Council scale are not equivalent when related to the maximal exercise capacity in COPD patients

Pulmonology, 2023
Introduction The management and treatment of Chronic Obstructive Pulmonary Disease (COPD) are based on a cutoff point either of ≥ 10 on the COPD Assessment Test (CAT) or of ≥ 2 of the Medical Research Council (mMRC).
R. Pisi, M. Aiello, L. Calzetta, A. Frizzelli, P. Tzani, G. Bertorelli, A. Chetta   +6 more
doaj   +1 more source

Investigational Treatments in Phase I and II Clinical Trials: A Systematic Review in Asthma

Biomedicines, 2022
Inhaled corticosteroids (ICS) remain the mainstay of asthma treatment, along with bronchodilators serving as control agents in combination with ICS or reliever therapy.
Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Elena Pistocchini, Beatrice Ludovica Ritondo, Paola Rogliani, Alfredo Chetta   +6 more
doaj   +1 more source

Stem Cell-Based Regenerative Therapy and Derived Products in COPD: A Systematic Review and Meta-Analysis

Cells, 2022
COPD is an incurable disorder, characterized by a progressive alveolar tissue destruction and defective mechanisms of repair and defense leading to emphysema.
Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Francesca Camardelli, Mario Cazzola, Paola Rogliani, Alfredo Chetta   +6 more
doaj   +1 more source

Impact of Sex on Proper Use of Inhaler Devices in Asthma and COPD: A Systematic Review and Meta-Analysis

Pharmaceutics, 2022
Despite females being more often affected by asthma than males and the prevalence of COPD rising in females, conflicting evidence exists as to whether sex may modulate the correct inhaler technique.
Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Beatrice Ludovica Ritondo, Elena Pistocchini, Paola Rogliani, Alfredo Chetta   +6 more
doaj   +1 more source

Clinical manifestations of a new alpha‐1 antitrypsin genetic variant: Q0parma

Respirology Case Reports, 2022
Alpha‐1 antitrypsin deficiency is an autosomal, codominant disorder caused by mutations of the SERPINA1 gene. Several mutations of SERPINA1 have been described associated with the development of pulmonary emphysema and/or chronic liver disease and ...
Marina Aiello, Annalisa Frizzelli, Laura Marchi, Ilaria Ferrarotti, Davide Piloni, Giovanna Pelà, Alessandro De Simoni, Lorenzo D'Aloisio, Luigino Calzetta, Alfredo Chetta   +9 more
doaj   +1 more source

Exercise intolerance in post-coronavirus disease 2019 survivors after hospitalisation

ERJ Open Research, 2023
Rationale Post-coronavirus disease 2019 (COVID-19) survivors frequently have dyspnoea that can lead to exercise intolerance and lower quality of life. Despite recent advances, the pathophysiological mechanisms of exercise intolerance in the post-COVID-19
Mariana L. Lafetá, Vitor C. Souza, Thaís C.F. Menezes, Carlos G.Y. Verrastro, Frederico J. Mancuso, André Luis P. Albuquerque, Suzana E. Tanni, Meyer Izbicki, Júlio P. Carlstron, Luiz Eduardo Nery, Rudolf K.F. Oliveira, Priscila A. Sperandio, Eloara V.M. Ferreira   +12 more
doaj   +1 more source

Clinical manifestations in patients with PI*MMMalton genotypes. A matter still unsolved in alpha‐1 antitrypsin deficiency

Respirology Case Reports, 2020
We report the genetic variants associated with alpha‐1 antitrypsin deficiency (AATD) in 117 patients admitted to our outpatient clinic and characterized by a serum concentration of AAT lower than 113 mg/dL.
Marina Aiello, Alberto Fantin, Chiara Longo, Ilaria Ferrarotti, Giuseppina Bertorelli, Alfredo Chetta   +5 more
doaj   +1 more source