The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022 Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee +16 more
wiley +1 more source
Mainstream Capnography Correlates Well with Central Venous Carbon Dioxide Levels in Non-intubated Children in PACU [PDF]
Journal of Clinical and Diagnostic Research, 2019 Introduction: Monitoring exhaled Carbon Dioxide (CO2 ) in nonintubated patients is challenging but has value for detecting hypoventilation, apnoea and hypercarbia. The study investigated a mainstream mask capnography system (cap-ONE®) especially designed
Abhishek Karnwal +7 more
doaj +1 more source
ABO blood group genotypes and ventilatory dysfunction in patients with allergic and nonallergic asthma [PDF]
Medicinski Glasnik, 2020 Aim ABO blood group genotypes are established as a genetic factor in pathophysiology of various diseases, such as cardiovascular disorders, cancers, infectious diseases and there is rising evidence of their involvement in other conditions.
Marina Lampalo +5 more
doaj +1 more source
A New Non-Negative Matrix Factorization Approach for Blind Source Separation of Cardiovascular and Respiratory Sound Based on the Periodicity of Heart and Lung Function [PDF]
arXiv, 2023 Auscultation provides a rich diversity of information to diagnose cardiovascular and respiratory diseases. However, sound auscultation is challenging due to noise. In this study, a modified version of the affine non-negative matrix factorization (NMF) approach is proposed to blindly separate lung and heart sounds recorded by a digital stethoscope. This
arxiv
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
COVID‐19 and the risk of Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1953-1961, December 2022., 2022 Abstract Background The coronavirus disease 2019 (COVID‐19) pandemic has had an unprecedented impact on the healthcare system, economy, and society. Studies have reported that COVID‐19 may cause various neurologic symptoms, including cognitive impairment.
Hanyu Zhang, Zengyuan Zhou
wiley +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Brain magnetic resonance imaging predictors in anti‐N‐methyl‐D‐aspartate receptor encephalitis
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1974-1984, December 2022., 2022 Abstract Objective Brain magnetic resonance imaging (MRI) findings in anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis are nonspecific and rarely have obvious associations with clinical characteristics and outcomes. This study aimed to comprehensively describe the MRI features of patients with NMDAR encephalitis, examine their associations with ...
Ying‐Ying Zhao +8 more
wiley +1 more source
Classify Respiratory Abnormality in Lung Sounds Using STFT and a Fine-Tuned ResNet18 Network [PDF]
arXiv, 2022 Recognizing patterns in lung sounds is crucial to detecting and monitoring respiratory diseases. Current techniques for analyzing respiratory sounds demand domain experts and are subject to interpretation. Hence an accurate and automatic respiratory sound classification system is desired.
arxiv
Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance
Molecular Oncology, EarlyView.In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang +8 more
wiley +1 more source