Results 81 to 90 of about 1,055,922 (317)

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Pseudomonas aeruginosa-Derived Volatile Sulfur Compounds Promote Distal Aspergillus fumigatus Growth and a Synergistic Pathogen-Pathogen Interaction That Increases Pathogenicity in Co-infection

Frontiers in Microbiology, 2019
Pathogen-pathogen interactions in polymicrobial infections are known to directly impact, often to worsen, disease outcomes. For example, co-infection with Pseudomonas aeruginosa and Aspergillus fumigatus, respectively the most common bacterial and fungal
Jennifer Scott, Monica Sueiro-Olivares, Waqar Ahmed, Waqar Ahmed, Christoph Heddergott, Can Zhao, Riba Thomas, Michael Bromley, Jean-Paul Latgé, Sven Krappmann, Stephen Fowler, Stephen Fowler, Elaine Bignell, Jorge Amich   +13 more
doaj   +1 more source

Absence of dry season Plasmodium parasitaemia, but high rates of reported acute respiratory infection and diarrhoea in presschool-aged children in Kaédi, southern Mauritania [PDF]

, 2012
BACKGROUND: The epidemiology of malaria in the Senegal River Gorgol valley, southern Mauritania, requires particular attention in the face of ongoing and predicted environmental and climate changes. While 'malaria cases' are reported in health facilities
Koïta Mohamedou, Bâ Ousmane, Sy Ibrahima, Koïta, Mohamedou, Keïta Moussa, Moussa Keïta, Ibrahima Sy, Salem, C. B., Traoré, D., Bâ, Ousmane, Utzinger Jürg, Salem Cheikh B Ould Ahmed, Traoré Doulo, Guéladio Cissé, Ould, Ahmed, Mohamedou Koïta, Touray, Sunkaru, Jürg Utzinger, Bâ, H., Mirko S Winkler, Sy, I., Bâ Hampâté, Hampâté Bâ, Keïta, M., Touray, S., Cissé, G., Doulo Traoré, Utzinger, J., Touray Sunkaru, Cissé Guéladio, Ousmane Bâ, Cheikh B Ould Ahmed Salem, Koïta, M., Sunkaru Touray, Bâ, O., Winkler, M. S., Bâ, Hampâté, Salem, Cheikh B. Ould Ahmed, Winkler Mirko S   +38 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection

Nature Communications, 2018
Mass screening diagnostics for Mycobacterium tuberculosis exist, but criticisms exist regarding the sensitivity and specificity of these tools. Here the authors use RNA-Seq and a modular bioinformatics approach using data from their own cohorts and meta ...
Akul Singhania, Raman Verma, Christine M. Graham, Jo Lee, Trang Tran, Matthew Richardson, Patrick Lecine, Philippe Leissner, Matthew P. R. Berry, Robert J. Wilkinson, Karine Kaiser, Marc Rodrigue, Gerrit Woltmann, Pranabashis Haldar, Anne O’Garra   +14 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Aspergillus fumigatus Gliotoxin Inhibits LC3-Associated Phagocytosis in Macrophages in a Calcium-Dependent Manner

Journal of Immunology Research
As a pivotal secondary metabolite of Aspergillus fumigatus, gliotoxin (GT) has many toxicological effects on mammalian cells; however, its function on LC3-associated phagocytosis (LAP) induced by A. fumigatus in macrophages is poorly understood. Here, it
Yuqing Sun, Fangyan Chen, Ling Zhang, Caopei Zheng, Yu Wang, Yulin Zhang, Li Han   +6 more
doaj   +1 more source

Trends in Group A Streptococcus Pharyngitis and Co-Infection with Severe Acute Respiratory Syndrome Coronavirus 2: A Retrospective Observational Study

Medicina
Background and Objectives: Group A Streptococcus (GAS) is a leading cause of acute pharyngitis with seasonal outbreaks. The coronavirus disease 2019 (COVID-19) pandemic significantly altered respiratory infection trends; however, its impact on GAS ...
Hidenori Takahashi, Yugo Satake, Saori Shimizu, Satomi Fujihara, Syunsuke Takano, Suzuko Fukasawa, Kaeyong Park, Naoya Toba, Takahiko Yano, Hiroki Nagamatsu, Ryutaro Hirose, Mio Toyama-Kousaka, Shinichiro Ota, Miwa Morikawa, Masaharu Shinkai   +14 more
doaj   +1 more source

Monitoring and evaluation of the immune status of female Kunming mice maintained in different biosafety level laboratories

Biology Open, 2018
High-level biosafety laboratories (BSL), such as BSL-3 and BSL-4, which deal with high infectivity and virulence pathogens, have become indispensable. Mice are frequently used in animal BSL (ABSL) to establish animal models for infection and to evaluate ...
Lei Guo, Yuan He, Heng Li, Yong Chen, Fanli Zhu, Mengli Yang, Chengyun Yang, Qing Dai, Haijing Shi, Longding Liu   +9 more
doaj   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source