Results 61 to 70 of about 1,055,922 (317)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A nested case–control study of predictors for tuberculosis recurrence in a large UK Centre

BMC Infectious Diseases, 2018
Background Tuberculosis (TB) recurrence represents a challenge to control programs. In low incidence countries, the prevailing risk factors leading to recurrence are poorly characterised.
Andrew Rosser, Matthew Richardson, Martin J. Wiselka, Robert C. Free, Gerrit Woltmann, Galina V. Mukamolova, Manish Pareek   +6 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Semiquantitative chest computed tomography scoring system to estimate severity in pediatric community-acquired pneumonia

Frontiers in Pediatrics
IntroductionA retrospective study assessed the utility of semiquantitative chest Computed tomography (CT) in diagnosing and determining the severity of community acquired pneumonia (CAP) in children.MethodsThe study included pediatric patients with CAP ...
Huifeng Fan, Xuehua Xu, Wangchun Dai, Diyuan Yang, Senqiang Zeng, Qiang Zeng, Gen Lu   +6 more
doaj   +1 more source

Molecular epidemiology of human rhinovirus infections in Kilifi, coastal Kenya [PDF]

, 2012
This study reports pediatric surveillance over 3 years for human rhinovirus (HRV) at the District Hospital of Kilifi, coastal Kenya. Nasopharyngeal samples were collected from children presenting at outpatient clinic with no signs of acute respiratory ...
Onyango, Clayton O., Agoti, Charles N., Bett, Ann, Cane, Patricia, Nokes, D. James, Munywoki, Patrick K., Welch, Stephen R., Ngama, Mwanajuma, Myers, Richard   +8 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus [PDF]

, 2010
Human and bovine respiratory syncytial viruses (HRSV and BRSV) are two closely related, worldwide prevalent viruses that are the leading cause of severe airway disease in children and calves, respectively.
Dubuquoy, Catherine, C., Eléouët, Jean-François, Soulestin, Marion, Deville, Sébastien, Durand, Guillaume, Meyer, Gilles, G., Bernard, Julie, Bernadet, Philippe, Bernardet, Philippe, Petit-Camurdan, Agnès, Schwartz-Cornil, Isabelle, Riffault, Sabine, Dubosclard, Virginie, Eleouet, Jean Francois, J. F., Meyer, Gilles, Castagné, Nathalie, Deplanche, Martine, Bernex, Florence, Dubuquoy, Catherine   +18 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

How often do healthy people cough?

Respiratory Research, 2023
Objective cough frequency has been reported in several respiratory conditions but the amount that healthy individuals cough daily is unclear. Seventy-nine healthy volunteers (38 males, median [IQR] age 41y [IQR 30–53]) completed 24-hour ambulatory cough ...
Kimberley J. Holt, Jaclyn A. Smith
doaj   +1 more source

Incidence and severity of respiratory syncytial virus pneumonia in rural Kenyan children identified through hospital surveillance [PDF]

, 2009
Background.Although necessary for developing a rationale for vaccination, the burden of severe respiratory syncytial virus (RSV) disease in children in resource‐poor settings remains poorly defined.
Medley, GF, Cane, Patricia A, Bett, A, Munywoki, P, Nokes, D. James, English, M. (Mike), Nokes, DJ, Scott, JA, Ngama, Mwanajuma, Ngama, M, Scott, J Anthony G, Medley, Graham F, Scott, John, Medley, Graham, English, M, Cane, Patricia, English, Mike, Munywoki, Patrick, Bett, Anne, Scott, J. Anthony G., Nokes, D James, Abwao, J, Abwao, John, Cane, PA   +23 more
core   +1 more source