Results 51 to 60 of about 952,092 (306)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

High Expression of IL-36γ in Influenza Patients Regulates Interferon Signaling Pathway and Causes Programmed Cell Death During Influenza Virus Infection

Frontiers in Immunology, 2020
As a severe complication of influenza infection, acute respiratory distress syndrome (ARDS) has higher morbidity and mortality. Although IL-36γ has been proven to promote inflammation at epithelial sites and protect against specific pathogen infection ...
Shuai Liu, Shuai Liu, Hui Li, Hui Li, Hui Li, Yeming Wang, Yeming Wang, Yeming Wang, Haibo Li, Haibo Li, Haibo Li, Sisi Du, Sisi Du, Sisi Du, Xiaohui Zou, Xiaohui Zou, Xiaohui Zou, Xulong Zhang, Bin Cao, Bin Cao, Bin Cao, Bin Cao   +21 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Achieving optimal technology and behavioral uptake of single and combined interventions of water, sanitation hygiene and nutrition, in an efficacy trial (WASH benefits) in rural Bangladesh

Trials, 2018
Background Uptake matters for evaluating the health impact of water, sanitation and hygiene (WASH) interventions. Many large-scale WASH interventions have been plagued by low uptake.
Sarker Masud Parvez, Rashidul Azad, Mahbubur Rahman, Leanne Unicomb, Pavani K. Ram, Abu Mohd Naser, Christine P. Stewart, Kaniz Jannat, Musarrat Jabeen Rahman, Elli Leontsini, Peter J. Winch, Stephen P. Luby   +11 more
doaj   +1 more source

Synergistic Activity of Colistin Combined With Auranofin Against Colistin-Resistant Gram-Negative Bacteria

Frontiers in Microbiology, 2021
Colistin-resistant (Col-R) bacteria are steadily increasing, and are extremely difficult to treat. New drugs or therapies are urgently needed to treat infections caused by these pathogens.
Xiaoxuan Feng, Xiaoxuan Feng, Shuai Liu, Shuai Liu, Yang Wang, Yang Wang, Yulin Zhang, Yulin Zhang, Yulin Zhang, Lingxiao Sun, Lingxiao Sun, Haibo Li, Haibo Li, Haibo Li, Chunlei Wang, Chunlei Wang, Chunlei Wang, Yingmei Liu, Yingmei Liu, Yingmei Liu, Bin Cao, Bin Cao, Bin Cao, Bin Cao, Bin Cao   +24 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The incidence and clinical burden of respiratory syncytial virus disease identified through hospital outpatient presentations in Kenyan children [PDF]

, 2012
There is little information that describe the burden of respiratory syncytial virus (RSV) associated disease in the tropical African outpatient setting. Methods We studied a systematic sample of children aged
Bett, Ann, Okiro Emelda A., D James Nokes, Ann Bett, Bett Ann, Emelda A Okiro, Ngama Mwanajuma, Nokes D. James, Nokes, D. James, Mwanajuma Ngama, Ngama, Mwanajuma, Okiro, Emelda A.   +11 more
core   +1 more source

Global distribution and characteristics of pneumococcal serotypes in adults

Human Vaccines & Immunotherapeutics
The introduction of pneumococcal conjugate vaccines (PCVs) into pediatric national immunization programs (NIP) has significantly reduced invasive pneumococcal diseases and pneumococcal pneumonia caused by PCV serotypes in adults due to herd immunity ...
Haruka Maeda, Konosuke Morimoto
doaj   +1 more source

Assessment of baseline age-specific antibody prevalence and incidence of infection to novel influenza A/H1N1 2009

Health Technology Assessment, 2010
Objectives: The objectives of the H1N1 2009 serological surveillance project were twofold: to document (1) the prevalence of cross-reactive antibodies to H1N1 2009 by age group in the population of England prior to arrival of the pandemic strain virus in
P Hardelid, NJ Andrews, K Hoschler, E Stanford, M Baguelin, PA Waight, M Zambon, E Miller   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source