Results 51 to 60 of about 882,341 (266)

Management Challenges and Outcomes of Bronchiolitis Obliterans Syndrome After Hematopoietic Stem Cell Transplantation: First Case Series Report From Vietnam

Case Reports in Hematology
Bronchiolitis obliterans syndrome (BOS) is a serious pulmonary manifestation of chronic graft-versus-host disease (cGvHD) after allogeneic hematopoietic stem cell transplantation (HSCT). Data from low- and middle-income countries remain scarce.
Luong Dinh-Van, Hoang-Anh Nguyen-Cong, Nguyen Tran-Ngoc, Bich-Ngoc T. Nguyen   +3 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Canadian Public Health Laboratory Network Statement on Point-of-Care Serology Testing in COVID-19

Canada Communicable Disease Report, 2022
Respiratory Virus Infections Working Group
doaj   +1 more source

Risk factors associated with the intensity of COVID-19 outbreaks in Canadian community settings: a retrospective analysis of outbreak-level surveillance data

BMC Public Health
Background The severity of COVID-19 outbreaks is disproportionate across settings (e.g., long-term care facilities (LTCF), schools) across Canada. Few studies have examined factors associated with outbreak severity to inform prevention and response.
Demy Dam, Michelle Chen, Erin E. Rees, Bethany Cheng, Lynn Sukkarieh, Erin McGill, Yasmina Tehami, Anna Bellos, Jonathan Edwin, Kaitlin Patterson   +9 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Hyponatremia as a “red flag” for concurrent meningitis in pulmonary cryptococcosis: a risk stratification model

BMC Neurology
Background Pulmonary cryptococcosis (PC) is increasingly diagnosed in human immunodeficiency virus (HIV)-negative and apparently immunocompetent individuals.
Bich-Ngoc T. Nguyen, Hoang-Anh Nguyen-Cong, Mai-Anh Nguyen, Minh-Phuong Duong, Thi-Chang Hoang, Van-Luong Dinh   +5 more
doaj   +1 more source

Case Report: Bilateral diaphragmatic dysfunction due to Borrelia Burgdorferi [v1; ref status: indexed, http://f1000r.es/4fe]

F1000Research, 2014
Summary: In this case report we describe a rare case of bilateral diaphragmatic dysfunction due to Lyme disease. Case report: A 62-years-old male presented to the hospital because of flu-like symptoms.
Suhail Basunaid, Chris van der Grinten, Nicole Cobben, Astrid Otte, Roy Sprooten, Rohde Gernot   +5 more
doaj   +1 more source