Results 51 to 60 of about 2,363,330 (306)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Duration of shedding of respiratory syncytial virus in a community study of Kenyan children [PDF]

, 2010
Background: Our understanding of the transmission dynamics of respiratory syncytial virus (RSV) infection will be better informed with improved data on the patterns of shedding in cases not limited only to hospital admissions.
Lisa J White, Medley, GF, Nokes, D. James, Nokes, DJ, Ngama, Mwanajuma, Ngama, M, Patricia A Cane, White, Lisa, D James Nokes, White, L. J., Okiro, E. A., Emelda A Okiro, Medley, Graham, Graham F Medley, Cane, Patricia, Okiro, EA, Mwanajuma Ngama, Cane, PA   +17 more
core   +2 more sources

Provision versus promotion to develop a handwashing station: the effect on desired handwashing behavior

BMC Public Health, 2017
Background Diarrhea prevalence increases from around the time that complementary foods are introduced. Improving caregiver’s hand hygiene during food preparation could reduce complementary food contamination and enteric pathogen transmission.
Debashish Biswas, Fosiul Alam Nizame, Tina Sanghvi, Sumitro Roy, Stephen P. Luby, Leanne E. Unicomb   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

The incidence and clinical burden of respiratory syncytial virus disease identified through hospital outpatient presentations in Kenyan children [PDF]

, 2012
There is little information that describe the burden of respiratory syncytial virus (RSV) associated disease in the tropical African outpatient setting. Methods We studied a systematic sample of children aged
Bett, Ann, Okiro Emelda A., D James Nokes, Ann Bett, Bett Ann, Emelda A Okiro, Ngama Mwanajuma, Nokes D. James, Nokes, D. James, Mwanajuma Ngama, Ngama, Mwanajuma, Okiro, Emelda A.   +11 more
core   +1 more source

Global distribution and characteristics of pneumococcal serotypes in adults

Human Vaccines & Immunotherapeutics
The introduction of pneumococcal conjugate vaccines (PCVs) into pediatric national immunization programs (NIP) has significantly reduced invasive pneumococcal diseases and pneumococcal pneumonia caused by PCV serotypes in adults due to herd immunity ...
Haruka Maeda, Konosuke Morimoto
doaj   +1 more source

Assessment of baseline age-specific antibody prevalence and incidence of infection to novel influenza A/H1N1 2009

Health Technology Assessment, 2010
Objectives: The objectives of the H1N1 2009 serological surveillance project were twofold: to document (1) the prevalence of cross-reactive antibodies to H1N1 2009 by age group in the population of England prior to arrival of the pandemic strain virus in
P Hardelid, NJ Andrews, K Hoschler, E Stanford, M Baguelin, PA Waight, M Zambon, E Miller   +7 more
doaj   +1 more source

Achieving optimal technology and behavioral uptake of single and combined interventions of water, sanitation hygiene and nutrition, in an efficacy trial (WASH benefits) in rural Bangladesh

Trials, 2018
Background Uptake matters for evaluating the health impact of water, sanitation and hygiene (WASH) interventions. Many large-scale WASH interventions have been plagued by low uptake.
Sarker Masud Parvez, Rashidul Azad, Mahbubur Rahman, Leanne Unicomb, Pavani K. Ram, Abu Mohd Naser, Christine P. Stewart, Kaniz Jannat, Musarrat Jabeen Rahman, Elli Leontsini, Peter J. Winch, Stephen P. Luby   +11 more
doaj   +1 more source

High Expression of IL-36γ in Influenza Patients Regulates Interferon Signaling Pathway and Causes Programmed Cell Death During Influenza Virus Infection

Frontiers in Immunology, 2020
As a severe complication of influenza infection, acute respiratory distress syndrome (ARDS) has higher morbidity and mortality. Although IL-36γ has been proven to promote inflammation at epithelial sites and protect against specific pathogen infection ...
Shuai Liu, Shuai Liu, Hui Li, Hui Li, Hui Li, Yeming Wang, Yeming Wang, Yeming Wang, Haibo Li, Haibo Li, Haibo Li, Sisi Du, Sisi Du, Sisi Du, Xiaohui Zou, Xiaohui Zou, Xiaohui Zou, Xulong Zhang, Bin Cao, Bin Cao, Bin Cao, Bin Cao   +21 more
doaj   +1 more source