Results 61 to 70 of about 2,363,330 (306)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysis [PDF]

, 2011
Background: Passive smoke exposure increases the risk of lower respiratory infection (LRI) in infants, but the extensive literature on this association has not been systematically reviewed for nearly ten years.
Hashim, Ahmed, Jones, Laura L; id_orcid, Leonardi-Bee, J, Ahmed Hashim, Derek G Cook, Britton, J, John Britton, Laura L Jones, Britton John, McKeever Tricia, Cook, Derek G, Leonardi-Bee, Jo, Jones, LL, Cook Derek G, McKeever, Tricia, Britton, John, Leonardi-Bee Jo, Hashim, A, Jo Leonardi-Bee, McKeever, T, Cook, DG, Hashim Ahmed, Jones Laura L, Tricia McKeever   +23 more
core   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The transmission dynamics of groups A and B human respiratory syncytial virus (hRSV) in England & Wales and Finland: seasonality and cross-protection [PDF]

, 2005
Human respiratory syncytial virus (hRSV) transmission dynamics are inherently cyclical, and the observed genetic diversity (between groups A and B) also appears to have a repeating pattern.
Waris, M, White, Lisa, Medley, GF, White, L. J., Medley, Graham, Waris, M., Cane, Patricia, Nokes, D. James, Nokes, DJ, White, LJ, Cane, PA   +10 more
core   +1 more source

Hesitancy towards COVID-19 booster vaccine among healthcare workers in Bangladesh

BMC Health Services Research
Background Despite completing the COVID-19 vaccination series, healthcare workers (HCWs) remain at an elevated risk of re-infection. Booster uptake, though essential for this group, remains poorly characterized among Bangladeshi HCWs.
Homayra Rahman Shoshi, Ahamed Khairul Basher, Ashrak Shad Pyash, Md. Kamal Hossain, Fahmida Chowdhury, Md Zakiul Hassan   +5 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Evidence of virus interference? Increased risk of non-influenza respiratory virus infections associated with receipt of inactivated influenza vaccine [PDF]

, 2012
BACKGROUND: Seasonal influenza vaccination is effective in preventing influenza infection and disease in healthy school-age children, while influenza vaccination is not generally thought to affect the risk of non-influenza respiratory virus infections (e.
Nishiura, H, Peiris, JSM, Cowling, BJ, Ip, DKM, Leung, GM, Chan, KH, Ng, S, Chiu, SS, Fang, VJ   +8 more
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

No temporal association between influenza outbreaks and invasive pneumococcal infections [PDF]

, 2008
Objective: To assess whether the influenza peak in populations precedes the annual peak for invasive pneumococcal infections (IPI) in winter.Design: Ecological study.
Toschke, Andre Michael, Arenz, Stephan, Höhle, Michael, Heininger, Ulrich, Weigl, Josef A. I., von Kries, Rüdiger, Puppe, Wolfram, Weigl, Josef A I, Kries, Wolfram and Weigl   +8 more
core   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source