Results 61 to 70 of about 882,341 (266)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Monitoring viral evolution and epidemiological characteristics of SARS-CoV-2 during 2022–2023 using Integrated Genomic Surveillance

Communications Medicine
Background The continued emergence of SARS-CoV-2 variants with increased transmissibility and immunoevasive properties highlights the necessity to complement genomic surveillance with epidemiological data and laboratory-based assessment of viral ...
Christin Mache, Romy Kerber, Jessica Schulze, Marie Lataretu, Susan Abunijela, Yusra Seyam, Sofia Paraskevopoulou, Djin-Ye Oh, Maximilian Arlt, Aleksandar Radonić, Somayyeh Sedaghatjoo, Matthias Budt, Ann-Sophie Lehfeld, Felix Hartkopf, Ralf Dürrwald, Torsten Semmler, Walter Haas, Stephan Fuchs, Stefan Kröger, Thorsten Wolff, Integrated Molecular Surveillance for SARS-CoV-2 (IMSSC2) Laboratory Network   +20 more
doaj   +1 more source

Clinical and Epidemiological Features of New Polyethiologic Viral Infections

Эпидемиология и вакцинопрофилактика, 2018
The review article summarizes and systematizes scientific data on the pathogens of new respiratory infections discovered in the early XXI century – Human metapneumovirus (HMPV), Human bocavirus (HBoV), Human coronavirus (HCoV).
V. V. Shkarin, O. V. Kovalyshen, R. F. Chanysheva, A. V. Sergeeva, A. A. Rassokhin   +4 more
doaj   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Comparison of long-term health-related quality of life and symptoms between COVID-19 patients and test-negative controls during the Omicron-predominant period in Japan

Archives of Public Health
Background Persistent symptoms following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affect health-related quality of life (HRQoL) and impose a substantial burden on society.
Haruka Maeda, Ataru Igarashi, Osamu Kuwamitsu, Konosuke Morimoto   +3 more
doaj   +1 more source

Quantification and determinants of the amount of respiratory syncytial virus (RSV) shed using real time PCR data from a longitudinal household study [version 2; referees: 2 approved, 2 approved with reservations]

Wellcome Open Research, 2017
Background A better understanding of respiratory syncytial virus (RSV) epidemiology requires realistic estimates of RSV shedding patterns, quantities shed, and identification of the related underlying factors.
Miriam Wathuo, Graham F. Medley, D. James Nokes, Patrick K. Munywoki   +3 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Characteristics of exhaled particle production in healthy volunteers: possible implications for infectious disease transmission [v1; ref status: indexed, http://f1000r.es/xa]

F1000Research, 2013
The size and concentration of exhaled particles may influence respiratory infection transmission risk. We assessed variation in exhaled particle production between individuals, factors associated with high production and stability over time.
Fatima Wurie, Olivier Le Polain de Waroux, Matthew Brande, Wesley DeHaan, Katherine Holdgate, Rishi Mannan, Donald Milton, Daniel Swerdlow, Andrew Hayward   +8 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Polysaccharides from Marine Bacteria and Their Anti-SARS-CoV-2 Activity

Microbiology Research
This study investigated the anti-SARS-CoV-2 activity of Polysaccharides (PSs) from three species of marine bacteria (Alteromonas nigrifaciens KMM 156, Cobetia amphilecti KMM 3890, and Idiomarina abyssalis KMM 227T).
Tatyana A. Kuznetsova, Natalia V. Krylova, Maksim S. Kokoulin, Elena V. Persiyanova, Olga S. Maistrovskaya, Pavel. G. Milovankin, Yurii A. Belov, Mikhail Yu. Shchelkanov   +7 more
doaj   +1 more source