Results 21 to 30 of about 43,117 (251)

The Impact of Increased PEEP on Hemodynamics, Respiratory Mechanics, and Oxygenation in Pediatric ARDS. [PDF]

Respir Care
BACKGROUND: PEEP is a cornerstone treatment for children with pediatric ARDS. Unfortunately, its titration is often performed solely by evaluating oxygen saturation, which can lead to inadequate PEEP level settings and consequent adverse effects.
Junqueira FM, Ferraz IS, Campos FJ, Matsumoto T, Brandão MB, Nogueira RJ, de Souza TH.   +6 more
europepmc   +2 more sources

Volume dependence of high-frequency respiratory mechanics in healthy adults [PDF]

, 2008
Respiratory system input impedance (Zrs) at low to medium frequencies below 100 Hz, and study of its volume dependence, have been used extensively to quantify airway and tissue mechanics.
Singh, Bhajan, Hantos, Zoltan, Kevin E. Finucane, Thamrin, Cindy, Finucane, Kevin E., Zoltán Hantos, Sly, Peter D., Finucane, Kevin E, Bhajan Singh, Peter D. Sly, Cindy Thamrin, Sly, Peter D   +11 more
core   +2 more sources

Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice

, 2009
The study aim was to establish how recruitment maneuvers (RMs) influence lung mechanics and to determine whether RMs produce lung injury. Healthy BALB/c mice were allocated to receive positive end-expiratory pressure (PEEP) at 2 or 6 cmH2O and volume ...
Sly, P.D., Hantos, Z, Sly, Peter D., Berry, L.J., Turner, D.J., Zosky, G R, Cannizzaro, V; https://orcid.org/, Turner, Debra J., Hantos, Zoltan, Cannizzaro, V., Berry, Luke J., Nicholls, P.K., Hantos, Z., Nicholls, P K, Sly, P D, Zosk, G.R., Zosky, Graeme R., Berry, L J, Cannizzaro, Vincenzo, Nicholls, Phillip K., Turner, D J   +20 more
core   +1 more source

Intra-breath respiratory mechanics of prematurity-associated lung disease phenotypes in school-aged children. [PDF]

ERJ Open Res
Intra-breath oscillometry potentially offers detailed information regarding airway function, with increasing magnitude of difference between resistance and reactance at end-expiration to end-inspiration potentially associated with obstructive airway ...
Cousins M, Hart K, Radics B, Henderson AJ, Hantos Z, Sly PD, Kotecha S.   +6 more
europepmc   +2 more sources

Comparing lung mechanics of patients with COVID related respiratory distress syndrome versus non-COVID acute respiratory distress syndrome: a retrospective observational study

, 2022
Background Most patients admitted to the intensive care unit with coronavirus disease (COVID-19) develop severe respiratory failure. Understanding lung mechanics helps to guide protective mechanical ventilation, improve oxygenation, and reduce the ...
Francisco Chacón-Lozsán, Péter Tamási   +1 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Changes in respiratory mechanics and gas exchange during the acute respiratory distress syndrome

, 2006
BACKGROUND: The time course of impairment of respiratory mechanics and gas exchange in the acute respiratory distress syndrome (ARDS) remains poorly defined. We assessed the changes in respiratory mechanics and gas exchange during ARDS.
Valta, P, Nunes, S, Takala, J
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source