Janus kinases inhibitors for coronavirus disease-2019: A pairwise and Bayesian network meta-analysis
BackgroundJAK (Janus kinases) inhibitors have been proposed as a promising treatment option for the coronavirus disease-2019 (COVID-19). However, the benefits of JAK inhibitors and the optimum thereof for COVID-19 have not been adequately defined ...
Jianyi Niu +18 more
doaj +1 more source
Noninvasive assessment of inspiratory muscle neuromechanical coupling during inspiratory threshold loading [PDF]
Diaphragm neuromechanical coupling (NMC), which reflects the efficiency of conversion of neural activation to transdiaphragmatic pressure (Pdi), is increasingly recognized to be a useful clinical index of diaphragm function and respiratory mechanics in ...
Estrada Petrocelli, Luis Carlos +6 more
core +2 more sources
Objectives A unique dataset of airway flow/pressure from healthy subjects on Continuous Positive Airway Pressure (CPAP) ventilation was collected. This data can be used to develop or validate models of pulmonary mechanics, and/or to develop methods to ...
Ella F. S. Guy +5 more
doaj +1 more source
Dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion [PDF]
Background: The ability of stroke volume variation (SVV), pulse pressure variation (PPV) and global end-diastolic volume (GEDV) for prediction of fluid responsiveness in presence of pleural effusion is unknown.
A Kumar +47 more
core +2 more sources
Respiratory decompensation with proning – when prone positioning can worsen respiratory mechanics
Prone positioning recently gain- ed more popularity from its use in COVID-19 management. It is gene-rally considered to improve respiratory mechanics via increased lung compliance.
Marko Oydanich +2 more
doaj +1 more source
MPI+X: task-based parallelization and dynamic load balance of finite element assembly [PDF]
The main computing tasks of a finite element code(FE) for solving partial differential equations (PDE's) are the algebraic system assembly and the iterative solver. This work focuses on the first task, in the context of a hybrid MPI+X paradigm.
Artigues, Antoni +6 more
core +4 more sources
How to measure respiratory mechanics during controlled mechanical ventilation
Bedside measurement of respiratory mechanics allows to closely monitor the lung function in critically ill patients. The two fundamental parameters describing the respiratory system mechanics are resistance and compliance.
Marco Giani +2 more
doaj +1 more source
Guanylyl cyclase activation reverses resistive breathing–induced lung injury and inflammation [PDF]
Inspiratory resistive breathing (RB), encountered in obstructive lung diseases, induces lung injury. The soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP) pathway is down-regulated in chronic and acute animal models of RB, such as ...
Brouckaert, Peter +15 more
core +2 more sources
Postperfusion lung syndrome: Respiratory mechanics, respiratory indices and biomarkers
Postperfusion lung syndrome is rare but lethal. Secondary inflammatory response was the popularly accepted theory for the underlying etiology. Respiratory index (RI) and arterial oxygen tension/fractional inspired oxygen can be reliable indices for the ...
Shi-Min Yuan
doaj +1 more source

